Results 91 to 100 of about 7,252,040 (293)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Objectives of method of choosing antiskid device settings

open access: yesВестник Научно-исследовательского института железнодорожного транспорта, 2016
At present there is a need to develop a method of braking calculations for rolling stock with antiskid devices. In other words, at the stage of designing the car (carriage) calculations must be produced proving that the planned parameters of antiskid ...
I. A. Zharov   +2 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

MHD stagnation flow of nanofluid past a permeable shrinking surface with various conditions [PDF]

open access: yes, 2018
The purpose of the present study is to analyze the effects of slip and heat source/sink on magnetohydrodynamic stagnation-point flow and heat transfer past a permeable shrinking surface with convective boundary condition.
Muhammad Hasri, Nurul ‘Izzati
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

The Extended Parameter Filter

open access: yes, 2013
The parameters of temporal models, such as dynamic Bayesian networks, may be modelled in a Bayesian context as static or atemporal variables that influence transition probabilities at every time step.
Erol, Yusuf   +3 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

RESEARCH OF BEHAVIOR OF TWO FIRMS BY MEANS OF VOLTERRA MODEL OF INTERACTION OF COMMUNITIES

open access: yesВестник Северо-Кавказского федерального университета, 2022
Coordinates of a steady steady state of model interaction of two firms are found in economy by comparison with two-specific Volterra model with any coefficients.
A. S. Adamchuk   +2 more
doaj  

Nonlinear calculation of earth pressures considering displacement effect

open access: yesYantu gongcheng xuebao, 2019
There is much difference between the calculated results of ultimate earth pressure theory and the experimental ones. To solve this problem, based on the Rankine's earth pressure theory and the two-parameter method, an earth pressure method considering ...
WANG Zheng-zhen 1, 2, GONG Wei-ming 1, 2, DAI Guo-liang 1, 2, LIU Xiao-guang 3, ZHAO Xin-xin 3, GUO Hui 3
doaj   +1 more source

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