Results 51 to 60 of about 850,606 (316)

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

A Transformer-Based Framework for Parameter Learning of a Land Surface Hydrological Process Model

Remote Sensing, 2023
The effective representation of land surface hydrological models strongly relies on spatially varying parameters that require calibration. Well-calibrated physical models can effectively propagate observed information to unobserved variables, but ...
Klin Li, Yutong Lu
doaj   +1 more source

Don't Fall for Tuning Parameters: Tuning-Free Variable Selection in High Dimensions With the TREX

, 2015
Lasso is a seminal contribution to high-dimensional statistics, but it hinges on a tuning parameter that is difficult to calibrate in practice. A partial remedy for this problem is Square-Root Lasso, because it inherently calibrates to the noise variance.
Lederer, Johannes, Müller, Christian
core   +1 more source

PERSONALISED BODY COUNTER CALIBRATION USING ANTHROPOMETRIC PARAMETERS

Radiation Protection Dosimetry, 2015
Current calibration methods for body counting offer personalisation for lung counting predominantly with respect to ratios of body mass and height. Chest wall thickness is used as an intermediate parameter. This work revises and extends these methods using a series of computational phantoms derived from medical imaging data in combination with ...
Pölz, S., Breustedt, B.
openaire   +4 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Calibration Method of PFC3D Micro-Parameters under Impact Load

Applied Sciences
Micro-parameter calibration is essential in constructing an accurate and reliable numerical model of particle discrete element PFC3D 6.0 software. Micro-parameter calibration is mainly accomplished according to the macro-parameters obtained from static ...
Zehua Zhang, Wenle Gao, Yuming Kou
doaj   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

FEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso, Jaime Hiniesta‐Valero, Alejandra Guerra‐Castellano, Miguel A. De la Rosa, Irene Díaz‐Moreno   +4 more
wiley   +1 more source

Explore parameter sensitivities and model calibration in a locally coupled environment [PDF]

, 2004
A locally coupled Single Column Model (SCM) was used for sensitivity analysis and model calibration. The sensitivity analysis was used to identify 32 land-surface parameters which appeared to be more or less sensitive in the locally coupled environment ...
Bastidas, LA, Gupta, HV, Liu, Y, Sorooshian, S   +3 more
core   +1 more source

Calibration biases in measurements of weak lensing

, 2011
As recently shown by Viola et al., the common (KSB) method for measuring weak gravitational shear creates a non-linear relation between the measured and the true shear of objects. We investigate here what effect such a non-linear calibration relation may
B. M. Schäfer, Bartelmann, Bartelmann, Bernstein, Bridle, Heymans, Hoekstra, Joachimi, Kaiser, Kuijken, M. Bartelmann, M. Viola, Melchior, Miller, P. Melchior, Schrabback, Viola, Voigt   +17 more
core   +1 more source