Results 151 to 160 of about 1,127,868 (280)

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Cauchy distribution optimizer for photovoltaic model parameter extraction and numerical optimization. [PDF]

Sci Rep
Fang D, Zhou Q, Jun Y, Guo S, Guo P.
europepmc   +1 more source

Three-dimensional cerebral vasculature topological parameter extraction of transgenic zebrafish embryos with a filling-enhancement deep learning network. [PDF]

Biomed Opt Express, 2023
Chen C, Chen C, Tang Y, Tan Y, Wang L, Li H.   +5 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Differential evolution with classified mutation for parameter extraction of photovoltaic models. [PDF]

PLoS One
Chen YG, Cao Y, Lu K, Yang Q, Chen Y, Ping Y.   +5 more
europepmc   +1 more source

Parameter extraction and selection for a scalable N-type SiC MOSFETs model and characteristic verification along with conventional dc-dc buck converter integration. [PDF]

PLoS One, 2023
Khalid H, Mekhilef S, Siddique MD, Wahyudie A, Ahmed M, Seyedmahmoudian M, Stojcevski A.   +6 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

An enhanced neural network algorithm and its applications for numerical optimization and parameter extraction of photovoltaic models. [PDF]

Sci Rep
Chi A, Mirjalili S, Zhang Y.
europepmc   +1 more source

Method for QCM Resonator Device Equivalent Circuit Parameter Extraction and Electrode Quality Assessment. [PDF]

Micromachines (Basel), 2021
Liu D, Xiao X, Tang Z, Chen Q, Li H, Wang X, Yan Y.   +6 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source