Results 111 to 120 of about 1,812,122 (351)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

The analysis of the 35 mm artillery projectile's motion model parameters' identification based on the recorded flight trajectory [PDF]

, 2018
Leszek Baranowski, Błażej Gadomski, Przemysław Majewski, Jacek Szymonik, Assiociate Professor, L Baranowski, L Baranowski, L Baranowski, B Gadomski, P Majewski, J Szymonik, L Baranowski, B Gadomski, P Majewski, J Szymonik, L Baranowski, M Kojdecki, V Cech, L Jedlicka, J Jevicky, P Champigny, D Ceroni, R Thepot, R Cayzac, E Carette, C Trouillot, O Donneaud, Y Chen, C Wen, Z Gong, M Sun, G Dutta, A Singhal, A Kushari, A Ghosh, K Motyl, M Magier, J Borkowski, B Zygmunt   +38 more
openalex   +1 more source

Identification of the Time-Varying Ventricular Parameters During the Ejection Phase of the Cardiac Cycle: The Martingale Optimality Principle Approach

, 2023
Ahmed S. Abutaleb
openalex   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Calibrating models in economic evaluation: a comparison of alternative measures of goodness of fit, parameter search strategies and convergence criteria.

, 2011
BACKGROUND: The importance of assessing the accuracy of health economic decision models is widely recognized. Many applied decision models (implicitly) assume that the process of identifying relevant values for a model's input parameters is sufficient to
Karnon, Jonathan, Vanni, Tazio
core   +1 more source

Data-Driven Electrode Parameter Identification for Vanadium Redox Flow Batteries Through Experimental and Numerical Methods

, 2020
Ziqiang Cheng, Kevin M. Tenny, Alberto Pizzolato, Antoni Forner‐Cuenca, Vittorio Verda, Yet‐Ming Chiang, Fikile R. Brushett, Reza Behrou   +7 more
openalex   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

On Identification of Bayesian DSGE Models [PDF]

In recent years there has been increasing concern about the identification of parameters in dynamic stochastic general equilibrium (DSGE) models. Given the structure of DSGE models it may be difficult to determine whether a parameter is identified.
Koop, Gary, Pesaran, Hashem, Smith, Ron P.   +2 more
core   +3 more sources

Identification of Ischemic Heart Disease by using machine learning\n technique based on parameters measuring Heart Rate Variability [PDF]

, 2020
Giulia Silveri, Marco Merlo, Luca Restivo, Beatrice De Paola, Aleksandar Miladinović, Miloš Ajčević, Gianfranco Sinagra, Agostino Accardo   +7 more
openalex   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source