Results 41 to 50 of about 1,939,164 (288)

Cuckoo Coupled Improved Grey Wolf Algorithm for PID Parameter Tuning

open access: yesApplied Sciences, 2023
In today’s automation control systems, the PID controller, as a core technology, is widely used to maintain the system output near the set value. However, in some complex control environments, such as the application of ball screw-driven rotating motors,
Ke Chen   +5 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

Advanced Thermal Management of Cylindrical Lithium-Ion Battery Packs in Electric Vehicles: A Comparative CFD Study of Vertical, Horizontal, and Optimised Liquid Cooling Designs

open access: yesBatteries
Battery packs found in electric vehicles (EVs) require thermal management systems to maintain safe operating temperatures in order to improve device performance and alleviate irregular temperatures that can cause irreversible damage to the cells ...
Michael Murphy, Mohammad Akrami
doaj   +1 more source

An adaptive Cuckoo search algorithm for optimisation

open access: yesApplied Computing and Informatics, 2018
Cuckoo search is one of many nature-inspired algorithms used extensively to solve optimisation problems in different fields of engineering. It is a very effective in solving global optimisation because it is able to maintain balance between local and ...
M. Mareli, B. Twala
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Power system stabiliser PSS4B-W parameters optimisation and RTDS test verification

open access: yesThe Journal of Engineering, 2019
This study introduces the mathematical model of a new type of power system stabiliser PSS4B-W. The concept of crossbreed in genetic algorithm is introduced to particle swarm optimisation algorithm and applied to ...
Siyuan Guo   +4 more
doaj   +1 more source

Covering Arrays ML HPO for Static Malware Detection

open access: yesEng, 2023
Malware classification is a well-known problem in computer security. Hyper-parameter optimisation (HPO) using covering arrays (CAs) is a novel approach that can enhance machine learning classifier accuracy. The tuning of machine learning (ML) classifiers
Fahad T. ALGorain, John A. Clark
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Parameter values before and after optimisation.

open access: yes, 2015
Parameter values before and after optimisation.
Nicola J. Robertson (322555)   +6 more
core   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

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