Results 41 to 50 of about 23,700 (266)

A Double Resistive–Capacitive Approach for the Analysis of a Hybrid Battery–Ultracapacitor Integration Study

Energies
The development of energy storage systems is significant for solving problems related to climate change. A hybrid energy storage system (HESS), combining batteries with ultracapacitors, may be a feasible way to improve the efficiency of electric vehicles
Adrian Chmielewski, Piotr Piórkowski, Krzysztof Bogdziński, Paweł Krawczyk, Jakub Lorencki, Artur Kopczyński, Jakub Możaryn, Ramon Costa-Castelló, Stepan Ozana   +8 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Robust Parameter Optimisation of Noise-Tolerant Clustering for DENCLUE Using Differential Evolution

Mathematics
Clustering samples based on similarity remains a significant challenge, especially when the goal is to accurately capture the underlying data clusters of complex arbitrary shapes.
Omer Ajmal, Humaira Arshad, Muhammad Asad Arshed, Saeed Ahmed, Shahzad Mumtaz   +4 more
doaj   +1 more source

Parametric Optimisation Analysis of Micro/Nano-Satellite Flywheels Based on the NSGA-Ⅱ Optimisation Algorithm

Aerospace, 2022
As the key mechanism of attitude control of micro/nano-satellites, the flywheel design is mostly based on empirical formulae that do not meet the requirements of lightweight and high-performance micro/nano-satellite platforms.
Wei Jiang, Weicheng Xie, Shuai Sun
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

IonBench: A benchmark of optimisation strategies for mathematical models of ion channel currents.

PLoS Computational Biology
Ion channel models present many challenging optimisation problems. These include unidentifiable parameters, noisy data, unobserved states, and a combination of both fast and slow timescales.
Matt J Owen, Gary R Mirams
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Optimisation of Parameters and Application of Green Recyclable Precast Hollow Steel Pipe Concrete Supports

Buildings
Underground space development is a crucial approach to addressing traffic congestion in China’s cities, especially through underground construction. However, the traditional pit internal support system, particularly the concrete internal support system ...
Ye Pan, Zhifeng Du, Haiguang Tian, Wenqiang Zhao, Tongju Xing, Zizhang Dong, Huadong Peng, Jianguo Zheng   +7 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source