Results 61 to 70 of about 23,700 (266)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

BRDF rendering by interpolation of optimised model parameters

Color and Imaging Conference, 2020
In this paper, we discuss an interpolation method which can be used to create a look up table to map tristimulus values to BRDF parameters. For a given tristimulus value, we interpolate the XYZ lattice formed by eight primaries and secondaries that were printed and measured, and their corresponding optimised BRDF parameters.
Habib, Tanzima, Green, Phil, Nussbaum, Peter   +2 more
openaire   +2 more sources

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

System architecture for mastering machine parameter optimisation

Computers in Industry, 2017
Abstract In mobile machines, as well as in manufacturing, the overall productivity is essential for business competitiveness. As the operation of a modern mobile machine is affected by various parameters, they need to be tuned to reach an optimal performance – however, due to machine complexity, parameter optimisation is difficult for a typical ...
Petri Kannisto, David Hästbacka, Seppo Kuikka   +2 more
openaire   +3 more sources

Layout Optimisation of Wave Energy Converter Arrays

Energies, 2017
This paper proposes an optimisation strategy for the layout design of wave energy converter (WEC) arrays. Optimal layouts are sought so as to maximise the absorbed power given a minimum q-factor, the minimum distance between WECs, and an area of ...
Pau Mercadé Ruiz, Vincenzo Nava, Mathew B. R. Topper, Pablo Ruiz Minguela, Francesco Ferri, Jens Peter Kofoed   +5 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Vibration reduction optimisation design of the high‐speed elevator car system based on multi‐factor horizontal coupling vibration model

IET Collaborative Intelligent Manufacturing
The increasing need for safe and comfortable high‐speed elevators due to the rise of super‐tall buildings has led to a focus on vibration reduction modelling and optimisation.
Meihao Chen, Zhaoxi Hong, Junjie Song, Tang Li, Xiuju Song, Yixiong Feng   +5 more
doaj   +1 more source

Parameter Tuning for Local-Search-Based Matheuristic Methods

Complexity, 2017
Algorithms that aim to solve optimisation problems by combining heuristics and mathematical programming have attracted researchers’ attention. These methods, also known as matheuristics, have been shown to perform especially well for large, complex ...
Guillermo Cabrera-Guerrero, Carolina Lagos, Carolina Castañeda, Franklin Johnson, Fernando Paredes, Enrique Cabrera   +5 more
doaj   +1 more source