FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Mathematical model of the process of converting waste oils into diesel biofuel
Наукові доповіді Національного університету біоресурсів і природокористування УкраїниThe growing demand for renewable energy sources encourages the development of technologies for the production of biodiesel from waste, but the high content of free fatty acids in raw materials complicates transesterification, reduces fuel yield, and ...
R. Chuiuk
doaj +1 more source
Learning as filtering: Implications for spike-based plasticity
PLoS Computational Biology, 2022 Most normative models in computational neuroscience describe the task of learning as the optimisation of a cost function with respect to a set of parameters.
Jannes Jegminat +2 more
doaj
How generalisable are material extrusion additive manufacturing parameter optimisation studies? A systematic review. [PDF]
Heliyon, 2022 Golab M, Massey S, Moultrie J.
europepmc +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
Slope Entropy Characterisation: An Asymmetric Approach to Threshold Parameters Role Analysis
EntropySlope Entropy (SlpEn) is a novel method recently proposed in the field of time series entropy estimation. In addition to the well-known embedded dimension parameter, m, used in other methods, it applies two additional thresholds, denoted as δ and γ, to ...
Mahdy Kouka +2 more
doaj +1 more source
Modelling and parameter optimisation for performance evaluation of sequencing batch reactor for treating hospital wastewater. [PDF]
Biomass Convers Biorefin, 2022 Khan NA +6 more
europepmc +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Patient-Specific Modelling and Parameter Optimisation to Simulate Dilated Cardiomyopathy in Children. [PDF]
Cardiovasc Eng Technol, 2022 Bozkurt S +3 more
europepmc +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source