Results 71 to 80 of about 1,939,164 (288)
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
DronesIn view of the difficulties encountered when tuning parameters and the lack of anti-interference capabilities exhibited by high-precision trajectory-tracking control of quadrotor UAVs in complex dynamic environments, this paper proposes a fusion control ...
Junhao Li, Junchi Bai, Jihong Wang
doaj +1 more source
Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2018 Bu çalışmada ASTM B574(Hastelloy C-22) malzemesi üzerinde tornalama işlemi sonrasında kesmeparametrelerinin (kesme derinliği, kesme hızı, radius, ilerleme hızı, debi,talaş açısı, yanaşma açısı) yüzey pürüzlüğü ve sıcaklık üzerindeki etkileriincelenmiştir.
Gültekin Basmacı +3 more
doaj +1 more source
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Parameter Tuning of Agent-Based Models: Metaheuristic Algorithms
MathematicsWhen it comes to modelling complex systems using an agent-based approach, there is a problem of choosing the appropriate parameter optimisation technique.
Andrei I. Vlad +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan +8 more
wiley +1 more source
A nature-inspired multi-objective optimisation strategy based on a new reduced space searching algorithm for the design of alloy steels [PDF]
, 2010 In this paper, a salient search and optimisation algorithm based on a new reduced space searching strategy, is presented. This algorithm originates from an idea which relates to a simple experience when humans search for an optimal solution to a ‘real ...
Mahfouf, Mahdi +3 more
core +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Multi-criteria calibration of a conceptual runoff model using a genetic algorithm [PDF]
Hydrology and Earth System Sciences, 2000 : Calibration of a model against more than one output variable is important for reliable simulations of internal processes. In this study, a genetic algorithm combined with local optimisation was proposed for automatic single- and multi-criteria ...
J. Seibert, J. Seibert
doaj
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source