Results 71 to 80 of about 1,479,521 (268)

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Seven-parameter PEMFC model optimization using an battlefield optimization algorithm

Electrochemistry Communications
Precise modeling of Proton Exchange Membrane Fuel Cells (PEMFCs) requires accurate identification of key parameters, which are often unavailable from manufacturers but crucial for predicting fuel cell performance.
Manish Kumar Singla, S.A. Muhammed Ali, Jyoti Gupta, Pradeep Jangir, Arpita, Ramesh Kumar, Reena Jangid, Mohammad Khishe   +7 more
doaj   +1 more source

Computer-aided diagnosis of lung nodule using gradient tree boosting and Bayesian optimization

, 2017
We aimed to evaluate computer-aided diagnosis (CADx) system for lung nodule classification focusing on (i) usefulness of gradient tree boosting (XGBoost) and (ii) effectiveness of parameter optimization using Bayesian optimization (Tree Parzen Estimator,
Kojima, Ryosuke, Kuroda, Tomohiro, Nishio, Mizuho, Nishizawa, Mitsuo, Sugiyama, Osamu, Togashi, Kaori, Yakami, Masahiro   +6 more
core   +2 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

An Interactive Approach for Hierarchical Parameter Optimization

Journal of Fluid Science and Technology, 2008
We propose a novel interactive parameter optimization technique which asks users to determine whether further exploration is required by using a hierarchical visualization technique. Our technique generates a k-d tree and uses the coefficient of multiple
Teppei TANAKA, Takayuki ITOH, Naohisa SAKAMOTO, Koji KOYAMADA   +3 more
doaj   +1 more source

Enhancing Differential Evolution With Novel Parameter Control

IEEE Access, 2020
In this paper, we proposed a novel DE variant named DE-NPC for real parameter single objective optimization. In DE-NPC algorithm, a novel adaptation scheme for the scale factor F is first proposed, which is based on the location information of the ...
Zhenyu Meng, Yuxin Chen, Xiaoqing Li
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

A novel hybrid genetic algorithm and Nelder-Mead approach and it’s application for parameter estimation [version 3; peer review: 2 approved, 1 approved with reservations]

F1000Research
Background Traditional optimization methods often struggle to balance global exploration and local refinement, particularly in complex real-world problems.
Neha Majhi, Rajashree Mishra
doaj   +1 more source

Process parameter optimization for lateral flow immunosensing

Materials Science for Energy Technologies, 2019
Lateral flow immunoassay (LFIA) is a widely used technique in the field of point-of-care diagnostics. Assembly of components such as sample pad, conjugate pad, nitrocellulose membrane (NCM), absorbent pad on the plastic backing laminate to prepare the ...
Vivek Borse, Rohit Srivastava
doaj   +1 more source