Results 71 to 80 of about 308,123 (247)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Comparison of process parameter optimization using different designs in nanoemulsion-based formulation for transdermal delivery of fullerene

International Journal of Nanomedicine, 2014
Cheng Loong Ngan,1 Mahiran Basri,1,2 Fui Fang Lye,1 Hamid Reza Fard Masoumi,1 Minaketan Tripathy,3,4 Roghayeh Abedi Karjiban,1 Emilia Abdul-Malek1 1Department of Chemistry, Faculty of Science, 2Halal Products Research Institute, Universiti Putra Malaysia,
Ngan CL, Basri M, Lye FF, Fard Masoumi HR, Tripathy M, Karjiban RA, Abdul-Malek E   +6 more
doaj  

Study on the Impact of Input Parameters on Seawater Dissolved Oxygen Prediction Models

Journal of Marine Science and Engineering
The concentration of dissolved oxygen (DO) in seawater is a core ecological indicator in aquaculture, and its accurate prediction is of great value for the management of marine ranching.
Wenqing Li, Jing Lv, Yuhang Wang, Xiangfeng Kong   +3 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Spaciotemporal optimization of mesh moving techniques for fluid-structure interactions

Nihon Kikai Gakkai ronbunshu, 2018
In mesh-based fluid-structure interaction (FSI) analysis, mesh moving techniques are essential for preventing mesh distortion and improving the robustness of FSI analysis.
Yuki YAMAMOTO, Giwon HONG, Naoto MITSUME, Tomonori YAMADA, Shinobu YOSHIMURA   +4 more
doaj   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

FEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso, Jaime Hiniesta‐Valero, Alejandra Guerra‐Castellano, Miguel A. De la Rosa, Irene Díaz‐Moreno   +4 more
wiley   +1 more source

Parameter Adaptive Manta Ray Foraging Optimization for Global Continuous Optimization Problems and Parameter Estimation of Solar Photovoltaic Models

International Journal of Computational Intelligence Systems
The manta ray foraging optimization (MRFO) algorithm suffers from a fixed parameter $$ S $$ S , limiting its adaptability in balancing search capability and convergence speed during different optimization stages.
Zhentao Tang, Kaiyu Wang, Yongxuan Yao, Mingxin Zhu, Lan Zhuang, Huiqin Chen, Jing Li, Li Yan, Shangce Gao   +8 more
doaj   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source