Results 61 to 70 of about 5,756,257 (288)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Consistent parameter clustering: definition and analysis. [PDF]
, 2007 Parameter clustering is a popular robust estimation technique based on location statistics in a parameter space where parameter samples are obtained from data samples.
Hillenbrand, Ulrich, Ulrich Hillenbrand
core
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
On using Directional Information for Parameter Space Decomposition in Ellipse Detection
, 1996 In this paper we use the parametric polar representation to extend the application of edge directional information from circle to ellipse extraction. As a result we obtain a mapping which decomposes the parameter space required for ellipse extraction ...
Nixon, M.S., Aguado, A.S., Montiel, M.E.
core +1 more source
Living Inside the UA Space Analog
Immediate accessThis item is made available by the University of Arizona Center for Human Space Exploration (CHaSE) with support from the University of Arizona Libraries.
Tresch, Trent
core +4 more sources
Parameter synthesis for Markov models: covering the parameter space [PDF]
Formal Methods in System DesignAbstractMarkov chain analysis is a key technique in formal verification. A practical obstacle is that all probabilities in Markov models need to be known. However, system quantities such as failure rates or packet loss ratios, etc. are often not—or only partially—known.
Junges, Sebastian +6 more
openaire +8 more sources
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
On a Uniparametric Class of Sixth-Order Multiple-Root Finders Using Rational Weighting
Fractal and FractionalThis investigation provides a comprehensive analytical framework for the topological morphology and global convergence dynamics governing a specific family of sixth-order iterative schemes designed for nonlinear equations with multiple roots. By invoking
Young Hee Geum
doaj +1 more source
Parameter Estimation on Homogeneous Spaces
IEEE Transactions on Signal ProcessingThe Fisher Information Metric (FIM) and the associated Cramér-Rao Bound (CRB) are fundamental tools in statistical signal processing, which inform the efficient design of experiments and algorithms for estimating the underlying parameters. In this article, we investigate these concepts for the case where the parameters lie on a homogeneous space ...
Shiraz Khan, Gregory S. Chirikjian
openaire +2 more sources
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source