Results 61 to 70 of about 14,986 (169)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Tracking discontinuities in parameter space

Journal of High Energy Physics
We develop a geometric framework in Feynman-parameter space to determine constraints on the sequential discontinuities of Feynman integrals. Our method is based on tracking the deformation of the integration contour as external kinematics are ...
Ruth Britto, Holmfridur S. Hannesdottir
doaj   +1 more source

Parameter-space topology of models for cell polarity

New Journal of Physics, 2014
Reaction–diffusion systems have been widely successful in the theoretical description of biological patterning phenomena, giving rise to numerous models based on differing mechanisms, mathematical implementations and parameter choices.
Philipp Khuc Trong, Ernesto M Nicola, Nathan W Goehring, K Vijay Kumar, Stephan W Grill   +4 more
doaj   +1 more source

Correction to: Investigating the parameter space of evolutionary algorithms

BioData Mining, 2019
Following publication of the original article [1], an error was reported in one of the experiments.
Moshe Sipper, Weixuan Fu, Karuna Ahuja, Jason H. Moore   +3 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Finding excesses in model parameter space

European Physical Journal C: Particles and Fields
Simulation-based inference (SBI) makes it possible to infer the parameters of a model from high-dimensional low-level features of the observed events. In this work we show how this method can be used to establish the presence of a weak signal on top of ...
Kierthika Chathirathas, Torben Ferber, Felix Kahlhoefer, Alessandro Morandini   +3 more
doaj   +1 more source

Rescuing leptogenesis parameter space of inverse seesaw

Physics Letters B
In a pure inverse seesaw framework, achieving a substantial lepton asymmetry that can be converted into the observed baryon asymmetry of the Universe is extremely challenging.
Ananya Mukherjee, Abhijit Kumar Saha
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Steering in the parameter space of a mode-locked laser [PDF]

EPJ Web of Conferences
The specific control of individual mode-locking states in an ultrafast laser requires knowledge about its phase space. We use a Mamyshev oscillator as a model nonlinear system to present an all-electronic manipulation and steering of nonlinear states ...
Repgen P., Şura A., Makey G., Ilday F. Ö.   +3 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source