Results 71 to 80 of about 5,756,257 (288)
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Exploring Parameter Space in Reinforcement Learning
Paladyn, 2010 This paper discusses parameter-based exploration methods for reinforcement learning. Parameter-based methods perturb parameters of a general function approximator directly, rather than adding noise to the resulting actions.
Rückstieß Thomas +5 more
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Parameter-space—Diffusion magnitude vs. s.d. of interaction strength σ.
, 2021 The figure shows statistics for 70 systems in diffusion magnitude vs. standard deviation parameter-space for panel A) Number of grid-points with oscillatory patterns, panel B) Average maximum phase shift for a species between grid-points if oscillations (
Susanne Pettersson (3929324) +1 more
core +1 more source
Spherical contours, IR divergences and the geometry of Feynman parameter integrands at one loop
Journal of High Energy Physics, 2020 Spherical contours introduced in [1] translate the concept of “discontinuity across a branch cut” to Feynman parameter space. In this paper, we further explore spherical contours and connect them to the computation of leading IR divergences of 1 loop ...
Akshay Yelleshpur Srikant
doaj +1 more source
Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
FEBS Letters, EarlyView.Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
wiley +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source
Structure Theory for Second Order 2D Superintegrable Systems with 1-Parameter Potentials [PDF]
, 2009 The structure theory for the quadratic algebra generated by first and second order constants of the motion for 2D second order superintegrable systems with nondegenerate (3-parameter) and or 2-parameter potentials is well understood, but the results for ...
Willard Miller Jr. +7 more
core +2 more sources
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source