Results 21 to 30 of about 691,873 (239)
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
The Higgs boson mass in a natural MSSM with nonuniversal gaugino masses at the GUT scale
, 2012 We identify a parameter region where the mass of the lightest CP-even Higgs boson resides in $124.4-126.8$ GeV, and at the same time the degree of tuning a Higgsino-mass parameter (so-called $\mu$-parameter) is relaxed above 10% in the minimal ...
Aad +41 more
core +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Longitudinal Cavity Mode Referenced Spline Tuning for Widely Tunable MG-Y Branch Semiconductor Laser [PDF]
, 2014 This paper presents a novel method for wavelength-continuous tuning of a MG-Y-Branch Laser that possesses an intrinsic self-calibration capability. The method utilizes the measured characteristic output power pattern caused by the internal longitudinal ...
Heininger, H.
core +1 more source
Fitting in a complex chi^2 landscape using an optimized hypersurface sampling
, 2011 Fitting a data set with a parametrized model can be seen geometrically as finding the global minimum of the chi^2 hypersurface, depending on a set of parameters {P_i}. This is usually done using the Levenberg-Marquardt algorithm.
A. Benveniste +11 more
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Confronting brane inflation with Planck and pre-Planck data
, 2013 In this paper, we compare brane inflation models with the Planck data and the pre-Planck data (which combines WMAP, ACT, SPT, BAO and H0 data). The Planck data prefer a spectral index less than unity at more than 5\sigma confidence level, and a running ...
Huang, Qing-Guo, Ma, Yin-Zhe, Zhang, Xin
core +1 more source