Results 31 to 40 of about 149,415 (266)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Hyper-parameter Tuning for Quantum Support Vector Machine

open access: yesAdvances in Electrical and Computer Engineering, 2022
In recent years, the positive effect of quantum techniques on machine learning methods have been studied. Especially in training big data, quantum computing is beneficial in terms of speed.
DEMIRTAS, F., TANYILDIZI, E.
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

A SARIMA APPROACH WITH PARAMETER OPTIMIZATION FOR ENHANCING FORECAST ACCURACY FOR NATIVE CHICKEN EGG PRODUCTION

open access: yesBarekeng
This study aims to accurately forecast monthly native chicken egg production using the Seasonal Autoregressive Integrated Moving Average (SARIMA) model with parameter optimization.
Rendra Gustriansyah   +3 more
doaj   +1 more source

Modeling and Non-Linear Self-Tuning Robust Trajectory Control of an Autonomous Underwater Vehicle [PDF]

open access: yesModeling, Identification and Control, 1988
A non-linear self-tuning algorithm is demonstrated for an autonomous underwater vehicle. Tighter control is achieved by a non-linear parameter identification algorithm which reduces the parameter uncertainty bounds.
Thor Inge Fossen, Jens G. Balchen
doaj   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

Technological progress in the formulation of primary logistics plans for refined oil and the construction of an intelligent parameter-tuning method

open access: yesYou-qi chuyun
ObjectiveThe development of primary logistics plans for refined oil currently relies heavily on logistics management software based on optimization models.
Guangtao FU   +7 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

On the Effectiveness of Parameter-Efficient Fine-Tuning

open access: yesProceedings of the AAAI Conference on Artificial Intelligence, 2023
Fine-tuning pre-trained models has been ubiquitously proven to be effective in a wide range of NLP tasks. However, fine-tuning the whole model is parameter inefficient as it always yields an entirely new model for each task. Currently, many research works propose to only fine-tune a small portion of the parameters while keeping most of the parameters ...
Zihao Fu   +5 more
openaire   +2 more sources

Home - About - Disclaimer - Privacy