Results 31 to 40 of about 1,981,405 (253)

Smaller is better: nanobodies meet NMR

open access: yesFEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

open access: yesFEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

A SARIMA APPROACH WITH PARAMETER OPTIMIZATION FOR ENHANCING FORECAST ACCURACY FOR NATIVE CHICKEN EGG PRODUCTION

open access: yesBarekeng
This study aims to accurately forecast monthly native chicken egg production using the Seasonal Autoregressive Integrated Moving Average (SARIMA) model with parameter optimization.
Rendra Gustriansyah   +3 more
doaj   +1 more source

Parameter values after tuning.

open access: yes, 2016
Parameter values after tuning.
Hashem Tamimi (3359189)   +2 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

PVP: Pre-trained Visual Parameter-Efficient Tuning [PDF]

open access: yes, 2023
Large-scale pre-trained transformers have demonstrated remarkable success in various computer vision tasks. However, it is still highly challenging to fully fine-tune these models for downstream tasks due to their high computational and storage costs ...
Hu, Qingyong   +5 more
core   +1 more source

Technological progress in the formulation of primary logistics plans for refined oil and the construction of an intelligent parameter-tuning method

open access: yesYou-qi chuyun
ObjectiveThe development of primary logistics plans for refined oil currently relies heavily on logistics management software based on optimization models.
Guangtao FU   +7 more
doaj   +1 more source

Calibration of tuning parameter for SWAM using empirical data.

open access: yes, 2022
We calibrated our tuning parameter using GEUVADIS data as our external validation. As a result, we set the default value of this tuning parameter to 3 in our software, which we believe performs best.
Hyun Min Kang (9690325)   +1 more
core   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

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