Results 41 to 50 of about 701,150 (283)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Modeling and Non-Linear Self-Tuning Robust Trajectory Control of an Autonomous Underwater Vehicle [PDF]

open access: yesModeling, Identification and Control, 1988
A non-linear self-tuning algorithm is demonstrated for an autonomous underwater vehicle. Tighter control is achieved by a non-linear parameter identification algorithm which reduces the parameter uncertainty bounds.
Thor Inge Fossen, Jens G. Balchen
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

A SARIMA APPROACH WITH PARAMETER OPTIMIZATION FOR ENHANCING FORECAST ACCURACY FOR NATIVE CHICKEN EGG PRODUCTION

open access: yesBarekeng
This study aims to accurately forecast monthly native chicken egg production using the Seasonal Autoregressive Integrated Moving Average (SARIMA) model with parameter optimization.
Rendra Gustriansyah   +3 more
doaj   +1 more source

Hyper-parameter Tuning for Quantum Support Vector Machine

open access: yesAdvances in Electrical and Computer Engineering, 2022
In recent years, the positive effect of quantum techniques on machine learning methods have been studied. Especially in training big data, quantum computing is beneficial in terms of speed.
DEMIRTAS, F., TANYILDIZI, E.
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

A Parameter Self-Tuning Rule Based on Spatial–Temporal Scale for Active Disturbance Rejection Control and Its Application in Flight Test Chamber Systems

open access: yesAerospace
Active disturbance rejection control (ADRC) emerges as a promising control approach due to its partial model-based characteristics and strong disturbance rejection capabilities.
Zhuang Xu   +5 more
doaj   +1 more source

Explore the Principles of Prompt Tuning and the Progress of Research [PDF]

open access: yesITM Web of Conferences
Prompt Tuning is a lightweight fine-tuning method that demonstrates efficient task adaptation and parameter efficiency for pre-trained language models (PLMs). Prompt Tuning highlights an important contribution to the advancement of NLP technology.
Zheng Tongxin
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

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