Results 161 to 170 of about 3,578 (213)

Development of a physiologically‐based pharmacokinetic model for Ritonavir characterizing exposure and drug interaction potential at both acute and steady‐state conditions

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 523-539, March 2025.
Abstract Ritonavir (RTV) is a potent CYP3A inhibitor that is widely used as a pharmacokinetic (PK) enhancer to increase exposure to select protease inhibitors. However, as a strong and complex perpetrator of CYP3A interactions, RTV can also enhance the exposure of other co‐administered CYP3A substrates, potentially causing toxicity.
Lien Thi Ngo, Woojin Jung, Tham Thi Bui, Hwi‐yeol Yun, Jung‐woo Chae, Jeremiah D. Momper   +5 more
wiley   +1 more source

A social-architecture perspective on gut microbiota dynamics and host physiology. [PDF]

Front Immunol
Ni Z, Zhou W, Gao Y.
europepmc   +1 more source

Optimal Homogeneous ℒp$$ {\boldsymbol{\mathcal{L}}}_{\boldsymbol{p}} $$‐Gain Controller

International Journal of Robust and Nonlinear Control, EarlyView.
ABSTRACT Nonlinear ℋ∞$$ {\mathscr{H}}_{\infty } $$‐controllers are designed for arbitrarily weighted, continuous homogeneous systems with a focus on systems affine in the control input. Based on the homogeneous ℒp$$ {\mathcal{L}}_p $$‐norm, the input–output behavior is quantified in terms of the homogeneous ℒp$$ {\mathcal{L}}_p $$‐gain as a ...
Daipeng Zhang, Benjamin Calmbach, Jaime A. Moreno, Johann Reger   +3 more
wiley   +1 more source

Targeting a genomic RNA G-quadruplex of dengue virus with small molecules as an alternative to protein-targeted therapeutics. [PDF]

J Biomed Sci
Kim YJ, Das M, Song J, Das S, Kim HJ, Kim JK, Lee KY, Kim KK, Lee HR.   +8 more
europepmc   +1 more source

Control Systems Design With Enlarged Stability Domains for Nonlinear Constrained Systems via Sum‐of‐Squares Optimization

International Journal of Robust and Nonlinear Control, EarlyView.
ABSTRACT Designing safe control laws for nonlinear systems is challenging, especially when ensuring stability under actuator saturation and state constraints. A key aspect is embedding controllers with a Region of Attraction (ROA), which defines initial conditions guaranteeing convergence to a stable equilibrium point (EP).
Bhaskar Biswas, Dmitry Ignatyev, Argyrios Zolotas, Antonios Tsourdos   +3 more
wiley   +1 more source

Regulation of skeletal muscle development and metabolism in broiler chickens by Urolithin A through threonine kinase 1 pathway activation. [PDF]

Poult Sci
Wu L, Peng L, Zhao X.
europepmc   +1 more source

Water‐Energy Nexus: Benchmarking the Energy Efficiency of Drinking Water Treatment Plants Accounting for Heterogeneity

Sustainable Development, EarlyView.
ABSTRACT The assessment of energy efficiency in water facilities is receiving increasing attention as a key strategy in the transition toward an energy‐neutral urban water cycle. This study evaluates the energy efficiency of 146 drinking water treatment plants (DWTPs) in Chile by applying a latent class stochastic frontier analysis (LCSFA) to account ...
Alexandros Maziotis, Maria Molinos‐Senante   +1 more
wiley   +1 more source

Image-Processing-Driven Modeling and Reconstruction of Traditional Patterns via Dual-Channel Detection and B-Spline Analysis. [PDF]

J Imaging
He X, Chen S, Kuang Y, Yang X.
europepmc   +1 more source

Assessing the Performance of European Union Regions in the “People” and “Prosperity” Pillars of the SDGs

Sustainable Development, EarlyView.
ABSTRACT This paper addresses the gap in subnational assessments of Sustainable Development Goals (SDGs) by benchmarking the performance of European Union NUTS‐2 regions in the People and Prosperity pillars of the 2030 Agenda for Sustainable Development.
Pablo Arocena, Pedro Pascual, Margarita Vega   +2 more
wiley   +1 more source

Synthetic Expansion of Blood Dielectric Spectra at Microwave Frequencies Using Data-Driven Methods. [PDF]

Sensors (Basel)
Alhummada I, Bialkowski A, Guo L, Villena Gonzales W, Deriche M, Abbosh A.   +5 more
europepmc   +1 more source