Results 171 to 180 of about 6,062,625 (214)

A gated hydrophobic funnel within BAX binds bioactive lipids to potentiate pro-apoptotic function. [PDF]

Nat Commun
Gelles JD, Chen Y, Luna-Vargas MPA, Viacava Follis A, Al Noman MA, Kabir M, Bayiokos SG, Mohammed JN, Sebastian TM, Pham ND, Shi Y, Jin J, Kriwacki RW, Chipuk JE.   +13 more
europepmc   +1 more source

Unsaturated biobased polyesters from bicyclic α‐pinene‐based diols

Polymer International, EarlyView.
We present the synthesis of four biosourced unsaturated polyesters made from chiral terpene‐based diols and esters of renewable diacids. The resulting materials harbor a bicyclic pinene ring in their backbones which leads to enhanced thermal properties while still conferring susceptibility to enzyme hydrolysis for chains having a cis alkene.
Ganapathy Ranjani, Shengwei Sun, Erik Sundén, Diana Bernin, Per‐Olof Syrén   +4 more
wiley   +1 more source

ViMST: vision transformer-based dual modality multi-task graph contrastive network for spatial transcriptomics microenvironments investigation. [PDF]

BMC Biol
Ding C, Liu Q, Zhao Y.
europepmc   +1 more source

Data‐Driven Prediction of Block Copolymer Morphology Using Coarse‐Grained Modeling and Machine Learning

Journal of Polymer Science, EarlyView.
An integrated framework combining high‐throughput CG‐MD simulations, automated image‐based feature extraction, and supervised machine learning enables efficient, interpretable, and data‐driven prediction of block copolymer morphological behaviors.
Lan Xu, Zhaofan Li, Wenjie Xia
wiley   +1 more source

Improved catalytic efficiency of P450 OleP for converting lithocholic acid into murideoxycholic and ursodeoxycholic acids through semi-rational and rational design. [PDF]

Synth Syst Biotechnol
Hu B, Pang C, Luo D, Wang Y, Sun C, Zhou J, Chen J, Du G, Zhong F, Zhou J, Wang B, Zhao X.   +11 more
europepmc   +1 more source

Geometric Intuition Enables Resource‐Efficient Screening for β‐Barrel‐Like Folds in Viral Structural Dark Matter

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Predicted protein structures now enable fold discovery beyond the reach of sequence homology, but scalable and interpretable methods remain limited. We present Cooper‐Beta, a resource‐efficient, chain‐resolved framework for detecting β‐barrel‐like folds from strand connectivity.
Shuyu Zhong, Yuying Jiang
wiley   +1 more source

Climate Change Threats to Medicinal Plants: Progress in Impact Assessments and Implications for Pharmaceutical Sustainability. [PDF]

Plants (Basel)
Cheng Y, Zhang Z.
europepmc   +1 more source

A minimal physiologically‐based pharmacokinetic modeling platform to predict intratumor exposure and receptor occupancy of an anti‐LAG‐3 monoclonal antibody

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 460-473, March 2025.
Abstract In oncology drug development, measuring drug concentrations at the tumor site and at the targeted receptor remains an ongoing challenge. Positron emission tomography (PET)‐imaging is a promising noninvasive method to quantify intratumor exposure of a radiolabeled drug (biodistribution data) and target saturation by treatment doses in vivo ...
Robin Michelet, Klas Petersson, Marc C. Huisman, C. Willemien Menke‐van der Houven van Oordt, Iris H. C. Miedema, Andrea Thiele, Ghazal Montaseri, Alejandro Pérez‐Pitarch, David Busse   +8 more
wiley   +1 more source

Chemoenzymatic Synthesis of Well-Defined α(2,8)- and α(2,9)-Linked Oligosialosides. [PDF]

Angew Chem Int Ed Engl
Fok JA, Kishor K, Bunyatov MI, Bosman GP, Boons GJ.   +4 more
europepmc   +1 more source

Development of a physiologically‐based pharmacokinetic model for Ritonavir characterizing exposure and drug interaction potential at both acute and steady‐state conditions

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 523-539, March 2025.
Abstract Ritonavir (RTV) is a potent CYP3A inhibitor that is widely used as a pharmacokinetic (PK) enhancer to increase exposure to select protease inhibitors. However, as a strong and complex perpetrator of CYP3A interactions, RTV can also enhance the exposure of other co‐administered CYP3A substrates, potentially causing toxicity.
Lien Thi Ngo, Woojin Jung, Tham Thi Bui, Hwi‐yeol Yun, Jung‐woo Chae, Jeremiah D. Momper   +5 more
wiley   +1 more source