Results 41 to 50 of about 29,740 (183)

Novel Antifungal Scaffold Targeting Tubulin Overcomes Sclerotinia Sclerotiorum Resistance

Advanced Science, EarlyView.
Addressing pesticide resistance, novel chromone‐acylhydrazone hybrids targeting fungal tubulin are synthesized. Compound G24 potently inhibited S. sclerotiorum (EC50 = 0.21µg mL−1) and demonstrated enhanced field performance via microencapsulation, offering a sustainable strategy against resistance and for global food security.
Lihui Shao, Xianqun Hu, Ying Wu, Xiang Zhou, Bo Zhang, Song Yang   +5 more
wiley   +1 more source

Systematically extending classical nucleation theory

, 2018
The foundation for any discussion of first-order phse transitions is Classical Nucleation Theory(CNT). CNT, developed in the first half of the twentieth century, is based on a number of heuristically plausible assumtptions and the majority of theoretical
Farkas L, James F Lutsko, Kashchiev D, Lutsko J F, Lutsko J F, Volmer M, Zeldovich J B   +6 more
core   +1 more source

Quantifying the Single‐Cell Morphological Landscape of Cellular Transdifferentiation through Force Field Reconstruction

Advanced Science, EarlyView.
This study reconstructs the driving force field of fibroblast‐to‐neuron transdifferentiation from sparse single‐cell images by decomposing it into flux and time‐dependent potential gradient, extending the landscape‐flux framework to non‐steady‐state systems.
Chudan Yu, Chuanbo Liu, Erkang Wang, Jin Wang   +3 more
wiley   +1 more source

$L^1$-optimality conditions for circular restricted three-body problems

, 2015
In this paper, the L1-minimization for the translational motion of a spacecraft in a circular restricted three-body problem (CRTBP) is considered. Necessary con- ditions are derived by using the Pontryagin Maximum Principle, revealing the existence of ...
Chen, Zheng
core   +3 more sources

Genetically Engineered Light‐Responsive In Situ Hydrogels for Immunomodulation and Multimodal Therapy in Metastatic Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Cysteine‐tagged silk‐elastin‐like proteins, a family of tri‐block chimeric proteins that consist of a photothermal agent binding motif, silk motif, and elastin motif is developed to form a responsive in situ hydrogel for late‐stage and metastatic triple‐negative breast cancer.
Xinchen Shen, Jiajia Zhang, Junhan Ou, Ziheng Bai, Tongyan Liu, Kaiyue Zhang, Kaixiang Zhu, James Q. Wang, Chaochen Wang, Qianting Zhang, Linrong Lu, Wenwen Huang   +11 more
wiley   +1 more source

Folic Acid‐Modified Ginger‐Derived Exosome‐Like Nanoparticles Co‐Delivering Sunitinib Suppress Renal Cell Carcinoma via PI3K‐Akt Pathway Inhibition, P‐gp Downregulation, and Macrophage Reprogramming

Advanced Science, EarlyView.
FPD‐GELNs co‐deliver Su and bioactive components. This active‐passive dual‐targeting strategy suppresses the progression of RCC through the following mechanisms: 1) inhibition of the PI3K‐Akt signaling pathway; 2) downregulation of ABCB1/P‐gp to enhance the chemosensitivity of RCC to Su; and 3) reprogramming of macrophages toward M1 polarization and ...
Haoyu Xu, Daixing Hu, Shixue Liu, Lei Yang, Junwu Li, Yuanyuan Bai, Guozhi Zhao, Wei Tang, Li Jiang   +8 more
wiley   +1 more source

Puerarin Targets MIC19 to Suppress Mitochondrial Metabolism of Tumor‐Infiltrating Tregs and Enhance Anti‐tumor Immunity

Advanced Science, EarlyView.
Puerarin targets mitochondrial MIC19 in tumor‐infiltrating Tregs, impairing their immunosuppressive function and enhancing antitumor immunity. This study uncovers the metabolic dependency of tumor‐infiltrating Tregs and highlights a potential metabolic‐targeted immunotherapeutic strategy for liver cancer. Abstract Regulatory T cells (Tregs) are pivotal
Yu Li, Ziyan Song, Jianjun Ding, Yiheng Zhou, Tianning Huang, Qufei Qian, Miao Yu, Wenzhao Chen, Jiazheng Liu, Ling Lu, Qiuyang Chen   +10 more
wiley   +1 more source

Hydro-chemical study of the evolution of interstellar pre-biotic molecules during the collapse of molecular clouds

, 2012
One of the stumbling blocks for studying the evolution of interstellar molecules is the lack of adequate knowledge of the rate co-efficients of various reactions which take place in the Interstellar medium and molecular clouds.
Ankan Das, Boogert, Chakrabarti, Chakrabarti, Chakrabarti, Cuppen, Das, Fuente, Gibb, Guelin, Ioppolo, Kuan, Liton Majumdar, Sandip K. Chakrabarti, Snyder, Sonali Chakrabarti, Woon   +16 more
core   +1 more source

HSP70 Interactome‐Mediated Proteolysis Targeting Chimera (HSP70‐PROTAC) for Ferroptosis‐Driven Cancer Treatment

Advanced Science, EarlyView.
This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.
Jinyun Dong, Yulong Li, Hui Liang, Zumei Wu, Shiqun Wang, Yichao Wang, Jieyu Xu, Yanning Lan, Maohua Cai, Guangzhao Pan, Haiyan Yang, Kai Miao, Zhe‐Sheng Chen, Fangfang Tao, Xuelei Ma, Jiang‐Jiang Qin   +15 more
wiley   +1 more source

Nonisotropic 3-level Quantum Systems: Complete Solutions for Minimum Time and Minimum Energy

, 2005
We apply techniques of subriemannian geometry on Lie groups and of optimal synthesis on 2-D manifolds to the population transfer problem in a three-level quantum system driven by two laser pulses, of arbitrary shape and frequency.
Boscain, Ugo, Chambrion, Thomas, Charlot, Gregoire   +2 more
core   +5 more sources