Results 111 to 120 of about 2,082,520 (309)

Development of Standardized Ethanol Extract of Fraxinus Griffithii as CNS Depressant [PDF]

, 2011
Background: Fraxinus griffithii has been widely used as CNS depressant. Its activity based on both empirical and preclinical data. However, standardization on raw material and process of extraction have not been conducted. Methods: Extraction of Fraxinus
., Sutarjadi, Hendrajaya, Kusuma, Kartini, Kartini, Kesuma, Dini, Kirtishanti, AgusIina, Soediman, Soediatmoko   +5 more
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Knowledge Extraction from Trained ANN River Water Quality Parameters [PDF]

Computational Engineering and Physical Modeling
Environmental factors, agricultural production and human health are impacted by the evaluation of water quality indicators: chemical oxygen demand (COD), Dissolved Oxygen (DO) and biological oxygen demand (BOD).
Pali Sahu, Shreenivas Londhe, Preeti Kulkarni   +2 more
doaj   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Computer Extraction of Electrocardiographic Parameters [PDF]

Circulation, 1962
C A, CACERES, C A, STEINBERG, S, ABRAHAM, W J, CARBERY, J M, McBRIDE, W E, TOLLES, A E, RIKLI   +6 more
openaire   +2 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

A Simplified Methodology for Solvent Screening in Selective Extraction of Lipids from Microalgae Based on Hansen Solubility Parameters

Molecules
Microalgae are considered a potential source of fatty acid esters that are suitable for biodiesel production. However, a principal bottleneck in lipids extraction is related to the selection of appropriate solvents in order to obtain an efficient process.
Costas Tsioptsias, Stefania Mitis, Alexandra Rentzela, Kalitsa Alvanou, Dimitra Kelesi, Christos Manolis, Anastasia Stergiou, Sotirios D. Kalamaras, Petros Samaras   +8 more
doaj   +1 more source

Tight-binding parameters from the full-potential linear muffin-tin orbital method: A feasibility study on NiAl

, 2002
We have examined a method of direct extraction of accurate tight-binding parameters from an ab-initio band-structure calculation. The linear muffin-tin potential method, in its full-potential implementation, has been used to provide the hamiltonian and ...
Altmann, Andersen, Andersen, Andersen, Andersen, Andersen, Andersen, Andersen, Andersen, Andersen, Andersen, Andersen, Ballentine, Beer, Bernstein, Bowler, Bullett, Cohen, Danos, Djajaputra, Djajaputra, Foulkes, Galli, Galli, Gaspard, Goedecker, Goedecker, Gonis, Goringe, Gunnarsson, Ham, Harris, Harrison, Haydock, Haydock, Heine, Hodges, Jayanthi, Kasowski, Kohn, Lenosky, Liberman, Loucks, Ma, Mattheiss, McKinnon, McMahan, McMahan, Mehl, Menon, Methfessel, Methfessel, Nemoshkalenko, Nguyen-Manh, Nozawa, Ohno, Papaconstantopoulos, Papaconstantopoulos, Papaconstantopoulos, Pettifor, Porezag, Press, Price, Price, Raabe, Riedinger, Röder, Sanchez-Portal, Savrasov, Sharma, Singh, Skriver, Slater, Slater, Springborg, Springborg, Talman, Tank, Turchi, Turek, Vargas, Weinert, Weissbluth, Williams, Wills, Xie, Yang, Yang, Yang, Ziman   +89 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source