Results 71 to 80 of about 1,920,538 (274)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Frontiers in StrokeIntroductionAlthough stroke is recognized as a chronic condition, estimates of different long-term outcomes after stroke are lacking in Africa. This study aimed to explore the profile, trajectory and determinants of long-term outcomes up to 4 years in a ...
Gabriel Ogunde +13 more
doaj +1 more source
Non-Parametric Maximum Likelihood Density Estimation and Simulation-Based Minimum Distance Estimators [PDF]
, 2010 Indirect inference estimators (i.e., simulation-based minimum distance estimators) in a parametric model that are based on auxiliary non-parametric maximum likelihood density estimators are shown to be asymptotically normal.
Gach, Florian, Pötscher, Benedikt M.
core +2 more sources
Semi-parametric regression: Efficiency gains from modeling the nonparametric part
, 2011 It is widely admitted that structured nonparametric modeling that circumvents the curse of dimensionality is important in nonparametric estimation. In this paper we show that the same holds for semi-parametric estimation.
Mammen, Enno +2 more
core +1 more source
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
BuildingsImproving the energy efficiency of Australia’s ageing housing stock is critical to achieving national decarbonisation and climate resilience goals. Although houses built prior to the introduction of national energy efficiency regulations in the 1990s are
Echo Chen +2 more
doaj +1 more source
Bibliometric Study of the Efficiency of Public Expenditure on Education
Revista CEA, 2020 This bibliometric study analyzes the literature on the efficiency of public education expenditure using two types of bibliometric indicators: quantity (number of publications) and quality (impact by year, author, and journal).
Juliana Arias-Ciro
doaj +1 more source
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
A General Approach to Optomechanical Parametric Instabilities
, 2009 We present a simple feedback description of parametric instabilities which can be applied to a variety of optical systems. Parametric instabilities are of particular interest to the field of gravitational-wave interferometry where high mechanical quality
Abbott +15 more
core +1 more source