Results 71 to 80 of about 591,132 (266)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Reframing BIM: Toward Epistemic Resilience in Existing-Building Representation
InfrastructuresConventional uses of building information modeling (BIM) in existing-building representation tend to prioritize geometric consistency and efficiency, but often at the expense of interpretive depth.
Ciera Hanson +2 more
doaj +1 more source
Lubricants, 2018 Hydraulic, reciprocating, polymeric seals are met in many engineering applications and are critical components for mechanism and machine reliability in industries including the automotive, marine, and aerospace industries.
George K. Nikas
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Proceedings of the ACM on Programming LanguagesThe work of Fuzz has pioneered the use of functional programming languages where types allow reasoning about the sensitivity of programs. Fuzz and subsequent work (e.g., DFuzz and Duet) use advanced technical devices like linear types, modal types, and partial evaluation.
Elisabet Lobo Vesga +3 more
openaire +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
CoRROrdered, linear, and other substructural type systems allow us to expose deep properties of programs at the syntactic level of types. In this paper, we develop a family of unary logical relations that allow us to prove consequences of parametricity for a range of substructural type systems.
C. B. Aberlé +2 more
openaire +4 more sources
Recent advances in terahertz parametric generation and detection using lithium niobate
Applied Physics ExpressWe have advanced the research and development of injection-seeded terahertz (THz) parametric generation and detection as a widely tunable, and coherent THz wave source and receiver, and have applied this technology to non-destructive spectroscopy and ...
Kodo Kawase, Sota Mine, Kosuke Murate
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source