Results 71 to 80 of about 617,160 (267)
Proceedings of the ACM on Programming LanguagesThe work of Fuzz has pioneered the use of functional programming languages where types allow reasoning about the sensitivity of programs. Fuzz and subsequent work (e.g., DFuzz and Duet) use advanced technical devices like linear types, modal types, and partial evaluation.
Elisabet Lobo Vesga +3 more
openaire +2 more sources
Soil and Water Research, 2015 Water quality and quantity in agricultural systems of arid and semi- arid regions of the world are of great importance. In this regard the trend to pressurized irrigation systems compared to surface irrigation, elevating water use efficiency, has ...
Ali BAGHERZADEH, Parisa PAYMARD
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
AgriculturePotato is one of the main agricultural commodities and has high economic value. Yield is a trait that becomes a benchmark for user (industry and farmers) in selecting and developing varieties.
Maulana Haris +10 more
doaj +1 more source
Estimator Statistics from Simulation-Free Dirichlet Block-Bootstrap Resampling
StatsSince the initiation of two variants of the bootstrap method by Efron and Rubin in the late 1970s, a variety of advancements has emerged in the literature. The subsampling of blocks enabled the estimation of the actual variance of the sample mean.
Tillmann Rosenow
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Reframing BIM: Toward Epistemic Resilience in Existing-Building Representation
InfrastructuresConventional uses of building information modeling (BIM) in existing-building representation tend to prioritize geometric consistency and efficiency, but often at the expense of interpretive depth.
Ciera Hanson +2 more
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source