Results 81 to 90 of about 552,495 (266)

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Modification of the Prony method for information-measuring systems

open access: yesИзвестия высших учебных заведений. Поволжский регион:Технические науки
Background. It is proposed to use a modified Prony algorithm based on a vector overdetermined model in problems of determining the parameters of complex-shaped signals. It is compared with the classical Prony method. The advantage of the modified Prony
N.V. Myasnikova   +3 more
doaj   +1 more source

Analysis of parametric models

open access: yesAdvances in Computational Mathematics, 2019
Parametric models in vector spaces are shown to possess an associated linear map. This linear operator leads directly to reproducing kernel Hilbert spaces and affine- / linear- representations in terms of tensor products. From the associated linear map analogues of covariance or rather correlation operators can be formed.
Matthies, Hermann, Ohayon, Roger
openaire   +3 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Analytical solution for mechanical behavior characterization of sandy dolomite tunneling

open access: yesFrontiers in Earth Science
Tunneling in sandy dolomite strata often faces hazards such as collapse, water inrush, and water–sand inrush, seriously threatening the safety of tunnel construction.
Di Sun   +19 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

A Parametrized Analysis of Algorithms on Hierarchical Graphs

open access: yesInternational Journal of Foundations of Computer Science, 2017
Hierarchical graphs are used in order to describe systems with a sequential composition of sub-systems. A hierarchical graph consists of a vector of subgraphs. Vertices in a subgraph may “call” other subgraphs. The reuse of subgraphs, possibly in a nested way, causes hierarchical graphs to be exponentially more succinct than equivalent flat graphs ...
Rachel Faran, Orna Kupferman
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

High-Gain Dual-Band Microstrip Antenna for 5G mmWave Applications: Design, Optimization, and Experimental Validation

open access: yesApplied Sciences
This study presents a novel dual-band microstrip antenna operating at 28/38 GHz, which is designed for fifth generation (5G) and next-generation communications.
Bilal Okan Icmez, Cetin Kurnaz
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

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