Results 1 to 10 of about 35,842 (214)

Biochemistry and Molecular Biology of MCA

open access: yesThe International Journal of Biological Markers, 1993
The mucin-like carcinoma-associated antigen (MCA) is a mucin with a molecular weight of 350 - 500 kD. It circulates in the serum and its serum content can be determined with the Cobas Core MCA EIA test. Patients with breast cancer show elevated MCA serum
A. Maurer, J. Burckhardt
doaj   +3 more sources

Biochemistry and Molecular Biology of Flaviviruses [PDF]

open access: yesChemical Reviews, 2018
Flaviviruses, such as dengue, Japanese encephalitis, tick-borne encephalitis, West Nile, yellow fever, and Zika viruses, are critically important human pathogens that sicken a staggeringly high number of humans every year. Most of these pathogens are transmitted by mosquitos, and not surprisingly, as the earth warms and human populations grow and move,
Nicholas J. Barrows   +10 more
openaire   +3 more sources

HDAC3 promotes macrophage pyroptosis via regulating histone deacetylation in acute lung injury

open access: yesiScience, 2023
Summary: Activated inflammation and pyroptosis in macrophage are closely associated with acute lung injury (ALI). Histone deacetylase 3 (HDAC3) serves as an important enzyme that could repress gene expression by mediating chromatin remodeling.
Ning Li   +9 more
doaj   +1 more source

G-quadruplex targeting chemical nucleases as a nonperturbative tool for analysis of cellular G-quadruplex DNA

open access: yesiScience, 2021
Summary: G-quadruplex structures are associated with various biological activities, while in vivo evidence is essential to confirm the formation of G-quadruplexes inside cells.
Zhen Yu   +2 more
doaj   +1 more source

The global Protein-RNA interaction map of ESRP1 defines a post-transcriptional program that is essential for epithelial cell function

open access: yesiScience, 2022
Summary: The epithelial splicing regulatory proteins, ESRP1 and ESRP2, are essential for mammalian development through the regulation of a global program of alternative splicing of genes involved in the maintenance of epithelial cell function. To further
Natoya J. Peart   +9 more
doaj   +1 more source

Biochemistry and Molecular Biology PBL Cases

open access: yesMedEdPORTAL, 2006
This resource is a collection of six problem-based learning (PBL) cases suitable for a biochemistry and molecular biology course taken by first- or second-year medical students.
Marshall Anderson
doaj   +1 more source

DNA facilitates heterodimerization between human transcription factors FoxP1 and FoxP2 by increasing their conformational flexibility

open access: yesiScience, 2023
Summary: Transcription factors regulate gene expression by binding to DNA. They have disordered regions and specific DNA-binding domains. Binding to DNA causes structural changes, including folding and interactions with other molecules.
Ricardo Coñuecar   +10 more
doaj   +1 more source

Structural basis for recognition and methylation of p97 by METTL21D, a valosin-containing protein lysine methyltransferase

open access: yesiScience, 2023
Summary: p97 is a human AAA+ (ATPase associated with diverse cellular activities, also known as valosin-containing protein [VCP]) ATPase, which is involved in diverse cellular processes such as membrane fusion and proteolysis.
Thang Quyet Nguyen   +5 more
doaj   +1 more source

Molecular biology and biochemistry of differentiation. [PDF]

open access: yesEnvironmental Health Perspectives, 1976
Recent work in the field of molecular biology and differentiation has been directed towards an assessment of the number of different genes involved in the development and differentiation process. By the techniques of RNA-DNA hybridization to single copy DNA, it appears that some 60,000-200,000 different RNA sequences are expressed during embryonic ...
openaire   +3 more sources

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