Results 31 to 40 of about 576,788 (310)

Dna2 nuclease resolves RNA:DNA hybrids at double-strand breaks

iScience
Summary: DNA double-strand breaks (DSBs) are highly detrimental to cells, as improper repair can result in inheritable genetic rearrangements or cell death.
Aditya Mojumdar, Courtney Granger, Martine Lunke, Ellis Evans, Jennifer A. Cobb   +4 more
doaj   +1 more source

Biochemistry [PDF]

, 2012
Over the recent years, biochemistry has become responsible for explaining living processes such that many scientists in the life sciences from agronomy to medicine are engaged in biochemical research.

core   +1 more source

Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel

iScience
Summary: SAMHD1 is a dNTP triphosphohydrolase governing nucleotide pool homeostasis and can detoxify chemotherapy metabolites controlling their clinical responses.
Si Min Zhang, Cynthia B.J. Paulin, Huazhang Shu, Miriam Yagüe-Capilla, Maurice Michel, Petra Marttila, Florian Ortis, Henri Colyn Bwanika, Christopher Dirks, Rajagopal Papagudi Venkatram, Elisée Wiita, Ann-Sofie Jemth, Ingrid Almlöf, Olga Loseva, Femke M. Hormann, Tobias Koolmeister, Erika Linde, Sun Lee, Sabin Llona-Minguez, Martin Haraldsson, Hanna Axelsson, Kia Strömberg, Evert J. Homan, Martin Scobie, Thomas Lundbäck, Thomas Helleday, Sean G. Rudd   +26 more
doaj   +1 more source

CRISPR as a strong gene editing tool [PDF]

, 2017
Clustered regularly-interspaced short palindromic repeats (CRISPR) is a new and effective genetic editing tool. CRISPR was initially found in bacteria to protect it from virus invasions.
Zheng, Xuexiu, Xuexiu Zheng, Haihong Shen, Loh, Tiing Jen, Shen, Haihong, Tiing Jen Loh, Shengfu Shen, Hongling Shen, Shen, Shengfu, Shen, Hongling   +9 more
core   +1 more source

UXT oligomerization is essential for its role as an autophagy adaptor

iScience
Summary: SQSTM1/p62 serves as an autophagy receptor that binds to ubiquitinated misfolded proteins and delivers them to the phagophores for removal. This function can be augmented by autophagy adaptors, such as UXT. Here, by in silico structural homology
Min Ji Yoon, Jugeon Park, MinHyeong Lee, Jiyeon Ohk, Tae Su Choi, Eun Jung Choi, Hosung Jung, Chungho Kim   +7 more
doaj   +1 more source

miR-374 promotes myocardial hypertrophy by negatively regulating vascular endothelial growth factor receptor-1 signaling [PDF]

, 2017
Vascular endothelial growth factor (VEGF) is an essential cytokine that has functions in the formation of new blood vessels and regression of cardiac hypertrophy.
Kim, Do Han, Chunghee Cho, Lee, Jong Sub, Jin Ock Kim, Cho, Chung Hee, Song, Dong Woo, Park, Jei Hyoung, Do Han Kim, Jong Sub Lee, Dong Woo Song, Kim, Jin Ock, Jei Hyoung Park   +11 more
core   +1 more source

Conserved LIR-specific interaction of Sigma-1 receptor and GABARAP

iScience
Summary: Among its various functions, the sigma-1 receptor (σ1R) has been reported to modulate macroautophagy. It is currently unknown how this activity is mediated. We phylogenetically, structurally, and biochemically analyzed σ1R regarding its function
Marius Wilhelm Baeken, Maximilian Christ, Daniel Schmitt, Wencke Trein, Heike Nagel, Albrecht Martin Clement, Hagen Körschgen, Christian Behl   +7 more
doaj   +1 more source

Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan, Michael Abele, Calogero Virgone, Michaela Kuhlen, Ricardo Lopez‐Almarez, Tal Ben‐Ami, Ewa Bien, Maja Cesen, Malgorzata A. Krawczyk, Andrea Ferrari, Gianni Bisogno, Yves Reguerre, Dominik T. Schneider, Louise Galmiche, Jorg Fuchs, Sarah Braungart, Bilgehan Yalcin, Ines B. Brecht, Daniel Orbach   +18 more
wiley   +1 more source

Biochemistry, molecular biology, and genetics. [PDF]

, 2014
Includes index.pharmacy bookfair2015Rev. ed. of: Biochemistry, molecular biology, and genetics / Todd A. Swanson, Sandra I. Kim, Marc J. Glucksman. 5th ed. c2010.ix, 449 p.
Lieberman, Michael, 1950-, Swanson, Todd A. Biochemistry, molecular biology, and genetics.   +1 more
core  

GSK-3β/β-TrCP regulates Nrf2-mediated oxidative stress response in Cristaria plicata

iScience
Summary: Nuclear factor erythroid 2-related factor 2 (Nrf2) orchestrates antioxidant and cytoprotective responses. Beyond classical Keap1-dependent redox regulation, Nrf2 activation can occur via the GSK-3β/β-TrCP pathway during Keap1 inhibition.
Yile Hu, Jinhua An, Han Qiu, Qinglian Wu, Jianqing Li, Gang Yang, Baoqing Hu, Chungen Wen   +7 more
doaj   +1 more source