Results 91 to 100 of about 140,769 (264)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Bayesian non-parametric ordinal regression under a monotonicity constraint

, 2022
Compared to the nominal scale, the ordinal scale for a categorical outcome variable has the property of making a monotonicity assumption for the covariate effects meaningful.
Saarela, Olli, Rohrbeck, Christian, Arjas, Elja   +2 more
core   +1 more source

Investigating the effects of biochars and zeolites in anaerobic digestion and co-digestion of cassava wastewater with livestock manure

Frontiers in Energy Research
The tangible effects of climate change and the influence of environmental factors on climate have driven a shift towards cleaner and more sustainable energy sources.
C. G. Achi, W. K. Kupolati, J. Snyman, J. M. Ndambuki, F. O. Fameso   +4 more
doaj   +1 more source

Settlement control of slurry shield tunnelling crossing adjacent buildings in mixed ground of round gravel and mudstone

Yantu gongcheng xuebao, 2017
The micro-disturbed construction in mixed ground is a major challenge in the shield tunnelling construction. The Nanning metro line 1 crossing You'ai buildings is confronted with the challenge of mixed ground of round gravel and mudstone.
XIE Xiong-yao 1, 2, WANG Qiang 1, 2, QI Yong 3, LI Jun 1, 2, YU Xing-guo 3
doaj   +1 more source

Parametric Functional Principal Component Analysis

Biometrics, 2017
Summary Functional principal component analysis (FPCA) is a popular approach in functional data analysis to explore major sources of variation in a sample of random curves. These major sources of variation are represented by functional principal components (FPCs).
Sang, Peijun, Wang, Liangliang, Cao, Jiguo   +2 more
openaire   +3 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Modification of the Prony method for information-measuring systems

Известия высших учебных заведений. Поволжский регион:Технические науки
Background. It is proposed to use a modified Prony algorithm based on a vector overdetermined model in problems of determining the parameters of complex-shaped signals. It is compared with the classical Prony method. The advantage of the modified Prony
N.V. Myasnikova, M.G. Myasnikova, B.V. Tsypin, L.A. Dolgikh   +3 more
doaj   +1 more source

Vehicle–Bridge Coupling of Road–Rail Dual-Use Network Arch Bridge Based on a Noniterative Approach: Parametric Analysis and Case Study

Buildings
In the realm of road–rail dual-use bridges, conducting accurate vehicle–bridge coupling analysis is crucial, as the combined effects of road traffic and rail transit induce complex dynamic challenges.
Haocheng Chang, Rujin Ma, Baixue Ge, Qiuying Zhu   +3 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

An efficient, parametric fixpoint algorithm for analysis of java bytecode

, 2007
interpretation has been widely used for the analysis of object-oriented languages and, in particular, Java source and bytecode. However, while most existing work deals with the problem of flnding expressive abstract domains that track accurately the ...
Mario Méndez, Manuel V. Hermenegildo, Navas, J., Hermenegildo, Manuel V., Navas, Jorge, Méndez-Lojo, Mario, Méndez, Mario, Jorge Navas   +7 more
core   +1 more source