Results 91 to 100 of about 552,495 (266)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
BuildingsLarge-scale concrete box girders are prone to early-age cracking because of the hydration reaction. To expedite the winter construction of large-scale precast box girders while mitigating the risk of thermal cracking induced by hydration heat, this study
Wei Yang +6 more
doaj +1 more source
, 2013 In a real-time system, it is crucial to ensure that all tasks of the system hold their deadlines. A missed deadline in a real-time system means that the system has not been able to function correctly. If the system is safety critical, this could potentially lead to disaster.
openaire +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
EngThis study proposes a design method for a novel bolted endplate rigid connection between circular concrete-filled steel tube (CCFT) columns and wide-flange (WF) steel beams, with particular emphasis on the parametric behavior governing joint performance.
Yu Gao, Dezhong Yu, Wenjun Gao
doaj +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Open EngineeringOne of the key variables that can affect energy consumption in a building is the shape of the structure. The current study aims to balance the using solar radiation (lighting, heating, and cooling) and energy consumption by analyzing climatic factors ...
Alhilo Intisar A. +1 more
doaj +1 more source
IEEE AccessWater pipeline leakages create significant environmental challenges worldwide. Machine learning (ML) is widely used for leakage detection, often based on time and frequency features.
David Barrientos-Torres +2 more
doaj +1 more source