Results 111 to 120 of about 552,495 (266)
Applied MechanicsTraditional expansion joints in bridge structures are prone to durability problems, such as leakage, corrosion, and high maintenance demands, which can significantly reduce service life.
Homa Haghighi, Girum Urgessa
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Applied SciencesThis study focuses on a novel three-span hybrid continuous beam bridge, analyzing the force performance and key design parameters of the non-cellular post-support plate joint.
Yiteng Lin +4 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
In-Plane Strain in Thin Film Peeling: A Numerical Study and a Unified Criterion for Stage Transition
MathematicsReleasing a thin film adhered to a rigid substrate by peeling is a fundamental issue in interfacial mechanics and is of practical significance in many fields including flexible electronics, heterogeneous integration, and advanced packaging.
Kunlun Li +4 more
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
BuildingsPrecast concrete (PC) structures are increasingly adopted in building construction for their sustainable construction advantages. However, theoretical models for seismic design of precast concrete walls with concrete-filled steel tubular (CFST) elements ...
Bian Wu, Min Zhang, Feng-Liang Zhang
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Understanding How Cationic Polymers' Properties Inform Toxic or Immunogenic Responses via Parametric Analysis. [PDF]
Macromolecules, 2023 Weiss AM +7 more
europepmc +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source