Results 121 to 130 of about 167,710 (314)

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

open access: yesFEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková   +3 more
wiley   +1 more source

Performance Comparison of Metaheuristic Optimization-Based Parametric Methods in Wind Turbine Power Curve Modeling

open access: yesIEEE Access
Wind-based power generation, which is a safe and clean energy resource, has a widespread implementation around the world to reduce the environmental pollution, alleviate the energy crisis and provide the economic benefits.
Mehmet Yesilbudak, Ahmet Ozcan
doaj   +1 more source

Non-parametric estimation of ROC curve

open access: yes, 2006
Receiver operating characteristic (ROC) curve is widely applied in measuring discriminatory ability of diagnostic or prognostic tests. This makes ROC analysis one of the most actively research areas in medical statistics.
Gu, Jiezhun   +2 more
core  

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

An explicit and rapid intersection algorithm of plane and NURBS surface in CNC surface machining

open access: yesScientific Reports
To address the challenge of plane-surface intersection in toolpath planning for CNC surface machining, a rapid intersection algorithm between a plane and a NURBS surface is proposed, which can provide an explicit Non-Uniform Rational B-Spline (NURBS ...
Shengli Wei   +3 more
doaj   +1 more source

Testing Linearity in Term Structures

open access: yes
Recent empirical studies suggests that affine models, a popular framework to analyse term structures of interest rates, are misspecified. This evidence is mainly based on time series properties of the data.
Peroni, Chiara
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Optimized non-parametric fragility curve estimation based on intensity measure data clustering and parametric model averaging

open access: yes, 2018
International audienceIn the context of seismic risk analysis, the mean annual rate of failure of a structure is computed by integrating the seismic fragility curve with respect to the seismic hazard curve.
Feau, C., Zentner, I., Trevlopoulos, K.
core   +2 more sources

Non-parametric news impact curve: a variational approach

open access: yes, 2016
URL des Documents de travail : http://ces.univ-paris1.fr/cesdp/cesdp2015.htmlDocuments de travail du Centre d'Economie de la Sorbonne 2015.86R - ISSN: 1955-611X - Version originale Septembre 2015, révisée en juillet 2016 Ancien titre : "A fully non ...
Goulet, Clément, Garcin, Matthieu
core  

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