Results 101 to 110 of about 167,710 (314)

基于VC++的平面尖点直动凸轮机构参数化设计

open access: yesJixie chuandong, 2013
The parametric drawing program of disc cam is discussed based on Visual C++ in SolidWorks.It re-alizes the parameter input,calculation and automatic generation of contour curve in the cam design.For straight moving part,it uses the template model that ...
王晨, 王宗彦, 吴淑芳, 秦慧斌
doaj  

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

ESTIMASI MODEL REGRESI SEMIPARAMETRIK MENGGUNAKAN ESTIMATOR KERNEL UNIFORM (Studi Kasus: Pasien DBD di RS Puri Raharja)

open access: yesE-Jurnal Matematika, 2015
Semiparametric regression model approach is a model approach that combines parametric regression models and nonparametric regression. On semiparametric regression, most explanatory variables are parametric and nonparametric others are.
ANNA FITRIANI   +2 more
doaj  

A hybrid spline-based parametric model for the yield curve

open access: yes, 2018
Empirical evidence indicates that both nominal and real yield curves in important markets have segmentation between their short end and their longer-maturity segments.
Almeida, Caio Ibsen Rodrigues de   +1 more
core   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

Normal Parametrizations of Algebraic Plane Curves

open access: yesJournal of Symbolic Computation, 2002
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +1 more source

The Lorenz curve in economics and econometrics [PDF]

open access: yes
This paper surveys selected applications of the Lorenz curve and related stochastic orders in economics and econometrics, with a bias towards problems in statistical distribution theory. These include characterizations of income distributions in terms of
Christian Kleiber
core  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

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