Results 81 to 90 of about 167,710 (314)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
ESTIMATING THE ROC CURVE AND ITS SIGNIFICANCE FOR CLASSIFICATION MODELS’ ASSESSMENT
Quantitative Methods in Economics, 2014 Article presents a ROC (receiver operating characteristic) curve and its application for classification models’ assessment. ROC curve, along with area under the receiver operating characteristic (AUC) is frequently used as a measure for the diagnostics ...
Ryszard Szupiluk +2 more
doaj
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Smooth parametric surfaces and n-sided patches
, 1989 The theory of 'geometric continuity' within the subject of CAGD is reviewed. In particular, we are concerned with how parametric surface patches for CAGD can be pieced together to form a smooth Ck surface.
Gregory, JA, Lau, VKH, Zhou, J
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Curve Graphing in MS Excel and Applications [PDF]
, 2007 Curve sketching is one of the best ways to visualize and investigate the behavior of functions and equations. Graphs convey a lot more information about functions than algebraic expressions would.
B Yushau, M El-Gebeily
core
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Parametric study of battery module cooling: Configuration optimization using response curve method
Results in EngineeringRecently, cylindrical lithium-ion battery cells have been widely used in electric vehicles due to efficient automated production and cheap kilowatt-hour capacity.
Daya Bandhu Ghimire +3 more
doaj +1 more source
Are monetary-policy reaction functions asymmetric?: The role of nonlinearity in the Phillips curve [PDF]
, 2005 This paper investigates the implications of a nonlinear Phillips curve for the derivation of optimal monetary policy rules. Combined with a quadratic loss function, the optimal policy is also nonlinear, with the policy-maker increasing interest rates by ...
Juan J. Dolado +5 more
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source