Results 51 to 60 of about 431,056 (283)

Analytical Solution for the Problem of Point Location in Arbitrary Planar Domains

Algorithms
This paper presents a general analytical solution for the problem of locating points in planar regions with an arbitrary geometry at the boundary. The proposed methodology overcomes the traditional solutions used for polygonal regions.
Vitor Santos
doaj   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Generating Algorithm for High Order Curve Based on ACO

ITM Web of Conferences, 2017
A generating algorithm for parametric curve based on ant colony optimization is proposed in this paper. In order to produce the maximum step efficiently, the ant colony optimization is used to search the optimal step of curve in forward.
Li Zhi-Jie, Duan Xiao-Dong, Lu Bo, Yun Jian   +3 more
doaj   +1 more source

Roullete curves, coin paradox and Aristotle’s wheel paradox [PDF]

Revista Brasileira de Ensino de Física
This work discusses the concept of roulette, the generated curves that occur when one curve rolls without slipping along another, tracing the path of a fixed point.
Osvaldo L. Santos-Pereira
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Algebraic Point Projection for Immersed Boundary Analysis on Low Degree NURBS Curves and Surfaces

Algorithms, 2020
Point projection is an important geometric need when boundaries described by parametric curves and surfaces are immersed in domains. In problems where an immersed parametric boundary evolves with time as in solidification or fracture analysis, the ...
Huanyu Liao, Pavan Kumar Vaitheeswaran, Tao Song, Ganesh Subbarayan   +3 more
doaj   +1 more source

An Intuitive Approach to Geometric Continuity for Parametric Curves and Surfaces (Extended Abstract) [PDF]

, 1985
The notion of geometric continuity is extended to an arbitrary order for curves and surfaces, and an intuitive development of constraints equations is presented that are necessary for it. The constraints result from a direct application of the univariate
Barsky, B. A., Derose, T. D.
core   +1 more source

Quantile Processes for Semi and Nonparametric Regression

, 2017
A collection of quantile curves provides a complete picture of conditional distributions. Properly centered and scaled versions of estimated curves at various quantile levels give rise to the so-called quantile regression process (QRP). In this paper, we
Chao, Shih-Kang, Cheng, Guang, Volgushev, Stanislav   +2 more
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source