Results 71 to 80 of about 2,181,691 (306)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Parametric vs. Semi-parametric Estimation of the Male-Female Wage Gap: An Application to France [PDF]

We use a semi-parametric method to decompose the difference in male and female wage densities into two parts-one explained by characteristics and one which is attributable to differences in returns to characteristics.
Robert Breunig, Sandrine Rospabe
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Parametric estimation analysis of compressive stress effects on piezoelectric properties of PZT ceramic

Journal of Asian Ceramic Societies
In this study, the frequency and capacitance of piezoelectric materials due to compressive stress were analyzed, and the overall material properties (compliance matrix, piezoelectric charge constant and dielectric constant) of piezoelectric ceramics were
Jong-Ho Kim, Il-Gok Hong, Ho-Yong Shin, Hyo-Jun Ahn, Jong-In Im   +4 more
doaj   +1 more source

On Two-Stage Non-Parametric Estimation [PDF]

The Annals of Mathematical Statistics, 1963
Abstract : A two-sample, two-stage non-parametric estimation problem is studied. The parameter phi phi(F, G) under consideration is estimable (i.e., there exists an unbiased estimator which is a function of independent observations from two populations with cumulative distribution functions F(X) and G(Y). (Hence, it is called a two-sample problem.) The
openaire   +3 more sources

Productivity improvement in Korean rice farming: parametric and non-parametric analysis [PDF]

The published empirical literature on frontier production functions is dominated by two broadly defined estimation approaches – parametric and non‐parametric.
Lee, Hyunok, Kwon, Oh Sang
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Comparison of terrestrial exospheric hydrogen 3D distributions at solar minimum and maximum using TWINS Lyman-α observations

Frontiers in Astronomy and Space Sciences
Remote sensing observations of far-ultraviolet (FUV) emissions have been used to estimate 3D neutral hydrogen (H) density models of the terrestrial exosphere under solar minimum (2008) and solar maximum (2013 and 2015) conditions.
Jochen H. Zoennchen, Gonzalo Cucho-Padin, Gonzalo Cucho-Padin, Lara Waldrop, Hans J. Fahr   +4 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Parametric a Priori-Aided Beamspace Channel Tracking for Terahertz Massive MIMO Systems

IEEE Access
Beamspace massive MIMO with a discrete lens array can significantly reduce the number of RF chains in terahertz systems. However, effective beam selection in such systems requires an accurate beamspace channel estimate, which is difficult to obtain under
Zaid Albataineh, Haythem Bany Salameh, Malik Umar   +2 more
doaj   +1 more source