Results 71 to 80 of about 606,425 (294)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Semi-nonparametric IV estimation of shape-invariant Engel curves [PDF]

open access: yes, 2007
This paper studies a shape-invariant Engel curve system with endogenous total expenditure, in which the shape-invariant specification involves a common shift parameter for each demographic group in a pooled system of nonparametric Engel curves.
Blundell, R., Chen, X., Kristensen, D.
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Maximal uniform convergence rates in parametric estimation problems [PDF]

open access: yes
This paper considers parametric estimation problems with independent, identically,non-regularly distributed data. It focuses on rate-effciency, in the sense of maximal possible convergence rates of stochastically bounded estimators, as an optimality ...
Daniel McFadden, Walter Beckert
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Parametric estimation analysis of compressive stress effects on piezoelectric properties of PZT ceramic

open access: yesJournal of Asian Ceramic Societies
In this study, the frequency and capacitance of piezoelectric materials due to compressive stress were analyzed, and the overall material properties (compliance matrix, piezoelectric charge constant and dielectric constant) of piezoelectric ceramics were
Jong-Ho Kim   +4 more
doaj   +1 more source

Local Parametric Estimation in High Frequency Data

open access: yes, 2018
In this paper, we give a general time-varying parameter model, where the multidimensional parameter possibly includes jumps. The quantity of interest is defined as the integrated value over time of the parameter process $\Theta = T^{-1} \int_0^T \theta_t^
Mykland, Per, Potiron, Yoann
core   +2 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Comparison of terrestrial exospheric hydrogen 3D distributions at solar minimum and maximum using TWINS Lyman-α observations

open access: yesFrontiers in Astronomy and Space Sciences
Remote sensing observations of far-ultraviolet (FUV) emissions have been used to estimate 3D neutral hydrogen (H) density models of the terrestrial exosphere under solar minimum (2008) and solar maximum (2013 and 2015) conditions.
Jochen H. Zoennchen   +4 more
doaj   +1 more source

Comparative analysis of power spectrum estimation methods

open access: yesLietuvos Matematikos Rinkinys, 2010
The subject of this paper is the comparative analysis of the eleven most important nonparametric, parametric and subspace power spectrum estimation methods.
Gintarė Petreikytė, Kazys Kazlauskas
doaj   +1 more source

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