Results 81 to 90 of about 881,566 (302)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Analytical treatment of in-plane parametrically excited undamped vibrations of simply supported parabolic arches

, 2003
The present work offers a simple and efficient analytical treatment of the in-plane un-damped vibrations of simply supported parabolic arches under parametric excitation.
Sophianopoulos, D. S., Sophianopoulos, DS, Michaltsos, G. T., Michaltsos, GT   +3 more
core   +1 more source

Application of first-order sensitivity analysis to stabilisation of unstable continuous multi-degree-of-freedom parametric periodic systems

Studia Geotechnica et Mechanica
From a practical point of view, the most important feature of a parametric periodic system is the instability phenomenon. Unlike in systems with constant coefficients, in which only points of instability exist, in parametric systems, whole areas of ...
Wójcicki Zbigniew
doaj   +1 more source

Theoretical and Numerical Analysis of 1 : 1 Main Parametric Resonance of Stayed Cable Considering Cable-Beam Coupling

Advances in Materials Science and Engineering, 2017
For the 1 : 1 main parametric resonances problems of cable-bridge coupling vibration, a main parametric resonances model considering cable-beam coupling is developed and dimensionless parametric resonances differential equations are derived.
Li-Na Zhang, Feng-Chen Li, Xiao-Yong Wang, Peng-Fei Cui   +3 more
doaj   +1 more source

Operating mechanism and optimization of dynamic absorber for a parametric excitation system

Nihon Kikai Gakkai ronbunshu, 2015
The effectiveness of a dynamic absorber for self-excited vibration, such as parametric resonance, has been known for several years. However, in the case of self-excited vibration, the operating mechanism of a dynamic absorber is still poorly understood ...
Tomoyuki TANIGUCHI, Takahiro KONDOU
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Efficient primary and parametric resonance excitation of bistable resonators

AIP Advances, 2016
We experimentally demonstrate an efficient approach to excite primary and parametric (up to the 4th) resonance of Microelectromechanical system MEMS arch resonators with large vibrational amplitudes.
A. Ramini, N. Alcheikh, S. Ilyas, M. I. Younis   +3 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Effect of Duffing nonlinearity on squeezing in a classical parametric amplifier in the unstable regime

Mechanical Engineering Journal
In quantum information processing, control of quantum entanglement is of central importance, particularly for applications in quantum computing. One established method for generating entanglement is squeezing, which exploits the uncertainty principle ...
Tomoki KANDA, Hiroshi YABUNO
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source