Results 111 to 120 of about 145,972 (266)
Fractional Mathieu Equation with Two Fractional Derivatives and Some Applications
Fractal and FractionalThe importance of this research comes from the several applications of the Mathieu equation and its generalizations in many scientific fields. Two models of fractional Mathieu equations are provided using Katugampola fractional derivatives in the sense ...
Ahmed Salem +2 more
doaj +1 more source
Four parametric extension of the Laplace transform
International Journal of Mathematical Analysis, 2021 Kiran Shahzadi +4 more
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Parametric 0–1 processes and extensive fuzzy sets
Stochastic Processes and their Applications, 1990 AbstractIn this paper the methods of random processes are used to establish the rigorous mathematical concepts of fuzzy sets and set up the concepts of extensive fuzzy sets. A 0–1 process determined by C on an index set T is called an extensive fuzzy set in T. As a special case, an independent 0–1 process is a fuzzy set.
openaire +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Hospitals universitários: avaliação comparativa de eficiência técnica
Economia Aplicada, 2000 This paper presents an exercise on comparative efficiency evaluation ofBrazilian federal university hospitals HUs (43 organizations). The methodology used is Data Envelopment Analysis - DEA, along with statistical non-parametric procedures and specific ...
Alexandre Marinho +1 more
doaj
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source