Results 111 to 120 of about 517,784 (313)

Semi-parametric Models for Satisfaction with Income

An overview is presented of some parametric and semi-parametric models, estimators, and specification tests that can be used to analyze ordered response variables.In particular, limited dependent variable models that generalize or-dered probit are ...
Bellemare, C., Melenberg, B., Soest, A.H.O. van   +2 more
core  

On parametric solution of fault detection problems

, 2011
We discuss the solution of the fault detection problem in presence of parametric uncertainties. The basic approach is an extension of the nullspace method for constant systems to the case of linear parameter varying (LPV) models.
Andras Varga, Varga, A.
core   +1 more source

Utilizing Artificial Neural Networks for Geometric Bone Model Reconstruction in Mandibular Prognathism Patients

Mathematics
Patient-specific 3D models of the human mandible are finding increasing utility in medical fields such as oral and maxillofacial surgery, orthodontics, dentistry, and forensic sciences.
Jelena Mitić, Nikola Vitković, Miroslav Trajanović, Filip Górski, Ancuţa Păcurar, Cristina Borzan, Emilia Sabău, Răzvan Păcurar   +7 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

A Simple GMM Estimator for the Semi-Parametric Mixed Proportional Hazard Model [PDF]

Ridder and Woutersen (2003) have shown that under a weak condition on the baseline hazard there exist root-N consistent estimators of the parameters in a semiparametric Mixed Proportional Hazard model with a parametric baseline hazard and unspecified ...
Ridder, Geert, Bijwaard, Govert
core  

Head and Neck Sarcoma Assessor (HaNSA) for treatment decisions using real-world data

ESMO Real World Data and Digital Oncology
Background: Head and neck sarcomas (HNS) are rare and diverse cancers with distinct biology, unique treatment constraints and poor survival outcomes. Furthermore, HNS are understudied in Asians, and prospective clinical trials are untenable.
M.Y.S. See, J.J.N. Goh, C.E. Low, C.E. Yau, W.S. Ong, R.X. Wong, N.F. Mohamed Noor, M.H.B.H. Mohamed, J.T. Suha, A.N.H. Sairi, W.L. Goh, X.Y. Woo, V.S. Yang   +12 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Data‐Driven Modeling for Urban Flood Warning Systems: A Case Study in the Guarará Basin, Brazil

Journal of Flood Risk Management
Urban flooding is a growing challenge in metropolitan areas, exacerbated by climate change and increasing urbanization. This study develops an innovative flood warning system for the Guarará Basin in Santo André, Brazil, leveraging both parametric and ...
Dário Hachisu Hossoda, Raphael Ferreira Perez, João Rafael Bergamaschi Tercini, Joaquin Ignácio Garcia Bonnecarrère   +3 more
doaj   +1 more source

A Bayesian semi-parametric model for thermal proteome profiling. [PDF]

Commun Biol, 2021
Fang S, Kirk PDW, Bantscheff M, Lilley KS, Crook OM.   +4 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source