Results 121 to 130 of about 14,495,757 (308)

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

open access: yesFEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Utilizing Artificial Neural Networks for Geometric Bone Model Reconstruction in Mandibular Prognathism Patients

open access: yesMathematics
Patient-specific 3D models of the human mandible are finding increasing utility in medical fields such as oral and maxillofacial surgery, orthodontics, dentistry, and forensic sciences.
Jelena Mitić   +7 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

open access: yesFEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Head and Neck Sarcoma Assessor (HaNSA) for treatment decisions using real-world data

open access: yesESMO Real World Data and Digital Oncology
Background: Head and neck sarcomas (HNS) are rare and diverse cancers with distinct biology, unique treatment constraints and poor survival outcomes. Furthermore, HNS are understudied in Asians, and prospective clinical trials are untenable.
M.Y.S. See   +12 more
doaj   +1 more source

Sub-series 2: Publications

open access: yes, 1989
Bimonthly magazine discussing topics related to aviation and model airplane engines including collecting, restoring, maintaining, and identifying engines, along with ...
The Model Museum
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Data‐Driven Modeling for Urban Flood Warning Systems: A Case Study in the Guarará Basin, Brazil

open access: yesJournal of Flood Risk Management
Urban flooding is a growing challenge in metropolitan areas, exacerbated by climate change and increasing urbanization. This study develops an innovative flood warning system for the Guarará Basin in Santo André, Brazil, leveraging both parametric and ...
Dário Hachisu Hossoda   +3 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

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