Results 101 to 110 of about 517,784 (313)
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Inference for copula modeling of discrete data: a cautionary tale and some facts
Dependence Modeling, 2017 In this note, we elucidate some of the mathematical, statistical and epistemological issues involved in using copulas to model discrete data. We contrast the possible use of (nonparametric) copula methods versus the problematic use of parametric copula ...
Faugeras Olivier P.
doaj +1 more source
A parametric model to jointly characterize rate, duration, and severity of exacerbations in episodic diseases. [PDF]
BMC Med Inform Decis Mak, 2023 Safari A +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
HMM-based Speech Synthesis with an Acoustic Glottal Source Model [PDF]
, 2009 A major cause of degradation of speech quality in HMM-based speech synthesis is the use of a simple delta pulse signal to generate the excitation of voiced speech. This paper describes a new approach to using an acoustic glottal source model in HMM-based
Renals, Steve +4 more
core
, 2022 reservedNowadays the world of engineering and architecture, through the use of new technologies is coming to develop buildings, infrastructures and cities always more complex.
ZANON, ANDREA
core
A Parametric Model for the Analysis of the Impedance Spectra of Dielectric Sensors in Curing Epoxy Resins. [PDF]
Sensors (Basel), 2023 Kyriazis A +4 more
europepmc +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Assessment Method for Urban Green Space Shading Based on the Allometric Parametric Model
Fengjing YuanlinObjectiveIn the context of accelerating urbanization and the escalating impacts of global warming, urban green spaces have become increasingly crucial for mitigating urban heat, as they offer shaded environments that significantly enhance the overall ...
Yujie CHEN +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source