Results 141 to 150 of about 2,932,686 (296)

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Autoregressive parametric modeling combined ANOVA approach for label-free-based cancerous and normal cells discrimination. [PDF]

Heliyon, 2021
AbdulGani AF, Al Ahmad M.
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Research on the efficient process-oriented structural optimization method of the large-scale vacuum cryostat for fusion reactors

Nuclear Fusion
An efficient optimization design for the large and complex components of fusion reactors is crucial to address the engineering design requirements and further promote technical standardization.
Qingzhou Yu, Hao Xu, Zhaoxi Chen, Qingxi Yang   +3 more
doaj   +1 more source

Multidisciplinary Design Optimization of Cooling Turbine Blade: An Integrated Approach with R/ICSM

Applied Sciences
This paper presents an efficient integrated multidisciplinary design optimization method for shaping a high-pressure cooling turbine blade in aero engines.
Wenjun Wang, Lan Xiang, Enzi Kang, Jiahao Xia, Shanguang Shi, Cunfu Wang, Cheng Yan   +6 more
doaj   +1 more source

Radiological assessment schedule for 1p/19q-codeleted gliomas during the surveillance period using parametric modeling. [PDF]

Neurooncol Adv, 2021
Kang H, Lee J, Ji SY, Choi SW, Kim KM, Lee JH, Lee ST, Won JK, Kim TM, Choi SH, Park SH, Moon KS, Kim CY, Yoo H, Nam DH, Kim JH, Kim Y, Park CK.   +17 more
europepmc   +1 more source

MatchIt: Nonparametric Preprocessing for Parametric Causal Inference [PDF]

MatchIt implements the suggestions of Ho, Imai, King, and Stuart (2007) for improving parametric statistical models by preprocessing data with nonparametric matching methods.
Elizabeth A. Stuart, Daniel Ho, Gary King, Kosuke Imai   +3 more
core  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Human Thoracolumbar Spine Tolerance to Injury and Mechanisms From Caudo-Cephalad Loading: A Parametric Modeling Study. [PDF]

J Eng Sci Med Diagn Ther, 2021
Yoganandan N, Khandelwal P, Porwal V, Humm J, Banerjee A.   +4 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source