Results 131 to 140 of about 2,932,686 (296)

Optimization-based scheme for nearly-zero energy multi-storied residential buildings with architectural design elements

open access: yesEnvironmental Research: Infrastructure and Sustainability
Global energy consumption has significantly increased as a result of the rise in appliance and equipment usage, which has been driven by technological improvements and economic expansion, particularly noticeable in the infrastructure and building ...
Shrutismita Talukdar   +2 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Automated Generation and Internal Force Visualization for Box Culvert Based on Building Information Modeling

open access: yesApplied Sciences
Box culverts, as a commonly employed structural form for culverts, play a critical role in traversing topographic barriers, ensuring the safety and smooth operation of transportation means such as roads and railways.
Dejiang Wang, Jiangming Huang
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Parametric-modeling-based multi-objective thermoelastic optimization of rudder structures

open access: yesMechanics & Industry
Lightweight optimization of rudder structures subjected to thermo-mechanical coupling is essential for high-speed aircraft but poses significant challenges.
Shi Guanghui   +6 more
doaj   +1 more source

Radiological assessment schedule for high-grade glioma patients during the surveillance period using parametric modeling. [PDF]

open access: yesNeuro Oncol, 2021
Ji SY   +11 more
europepmc   +1 more source

NON-PARAMETRIC AND SEMI-PARAMETRIC TECHNIQUES FOR MODELING AND SIMULATING CORRELATED, NON-NORMAL PRICE AND YIELD DISTRIBUTIONS: APPLICATIONS TO RISK ANALYSIS IN KANSAS AGRICULTURE [PDF]

open access: yes
Parametric, non-parametric, and semi-parametric approaches are commonly used for modeling correlated distributions. Semi-parametric and non-parametric approaches are used to examine the risk situation for Kansas agriculture.
Kastens, Terry L.   +1 more
core  

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