Results 121 to 130 of about 24,899,885 (305)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Design of the Initiative Parameterization Accurate 3D Model of ZA Worm gear and Worm

Jixie chuandong, 2015
The tooth surface of worm gear of ZA-type worm gear and worm transmission is spatial conjugate surface of complex worm cylindrical spiral surface,the mathematical equations describing of the worm gear tooth surface is complex,parametric accurate modeling
Liu Guangwu, Hou Hongsheng, Tang Yangyang   +2 more
doaj  

Parametric Modeling and Optimization of Dimensional Error and Surface Roughness of Fused Deposition Modeling Printed Polyethylene Terephthalate Glycol Parts. [PDF]

Polymers (Basel), 2023
Mishra P, Sood S, Bharadwaj V, Aggarwal A, Khanna P.   +4 more
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Automated Generation and Internal Force Visualization for Box Culvert Based on Building Information Modeling

Applied Sciences
Box culverts, as a commonly employed structural form for culverts, play a critical role in traversing topographic barriers, ensuring the safety and smooth operation of transportation means such as roads and railways.
Dejiang Wang, Jiangming Huang
doaj   +1 more source

Influence of Meso-Scale Pore Structure on Mechanical Behavior of Concrete under Uniaxial Compression Based on Parametric Modeling. [PDF]

Materials (Basel), 2022
Yang H, Zhu E, Liu L.
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Parametric-modeling-based multi-objective thermoelastic optimization of rudder structures

Mechanics & Industry
Lightweight optimization of rudder structures subjected to thermo-mechanical coupling is essential for high-speed aircraft but poses significant challenges.
Shi Guanghui, Bao Yuhao, Wu Wenhua, Guo Guiqiang, Lin Ye, Zhang Xiaopeng, Tao Ran   +6 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Radiological assessment schedule for high-grade glioma patients during the surveillance period using parametric modeling. [PDF]

Neuro Oncol, 2021
Ji SY, Lee J, Lee JH, Lee ST, Won JK, Kim JW, Kim YH, Kim TM, Choi SH, Park SH, Kim Y, Park CK.   +11 more
europepmc   +1 more source