Results 111 to 120 of about 24,899,885 (305)

Parametric modeling and analysis of intake phases for side-ported Wankel rotary engines. [PDF]

Heliyon, 2023
Wang H, Ji C, Yang J, Ge Y, Zambalov S, Yakovlev I.   +5 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Development of knowledge based parametric CAD modeling system for spur gear: An approach

, 2018
In almost every mechanism, gears are extensively used machine parts to transmit power from one shaft to other with or without change of speed or direction.
E. J. Reddy, V. P. Rangadu
semanticscholar   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Causal, Bayesian, & non-parametric modeling of the SARS-CoV-2 viral load distribution vs. patient's age. [PDF]

PLoS One, 2022
Guardiani M, Frank P, Kostić A, Edenhofer G, Roth J, Uhlmann B, Enßlin T.   +6 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Robust parametric modeling of Alzheimer's disease progression. [PDF]

Neuroimage, 2021
Mehdipour Ghazi M, Nielsen M, Pai A, Modat M, Jorge Cardoso M, Ourselin S, Sørensen L.   +6 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Optimization-based scheme for nearly-zero energy multi-storied residential buildings with architectural design elements

Environmental Research: Infrastructure and Sustainability
Global energy consumption has significantly increased as a result of the rise in appliance and equipment usage, which has been driven by technological improvements and economic expansion, particularly noticeable in the infrastructure and building ...
Shrutismita Talukdar, Subhrajit Dutta, Golam Kabir   +2 more
doaj   +1 more source

Bayesian parametric modeling of time to tuberculosis co-infection of HIV/AIDS patients at Jimma Medical Center, Ethiopia. [PDF]

Sci Rep, 2022
Umeta AK, Yermosa SF, Dufera AG.
europepmc   +1 more source