Results 61 to 70 of about 382,396 (276)

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

3D PARAMETRIC MODELLING DEDICATED TO GROUP TECHNOLOGY

Journal of Industrial Design and Engineering Graphics, 2015
The parametric geometric modelling, fundamental instrument of CAD, has laid the groundwork for important changes in this area. Thus, the parametric modelling has contributed to optimal design of the products and has led to increase of the design ...
DUMITRACHE Petru
doaj  

Conceptual Design of Compliant Structures for Morphing Wingtips Using Single-Row Corrugated Panels

Aerospace
Morphing wingtips have the potential to improve aircraft performance. By connecting the wingtips and the wings with a compliant structure, a continuous aerodynamic surface can be achieved for a better aerodynamic performance. However, how to maintain the
Ziyi He, Siyun Fan, Chen Wang, Songqi Li, Yan Zhao, Xing Shen, Jiaying Zhang   +6 more
doaj   +1 more source

Modeling Roman Pavements Using Heritage-BIM: A Case Study in Pompeii

The Baltic Journal of Road and Bridge Engineering, 2020
The study of ancient stone pavements represents the necessary premise for planning and execution of treatments that considers the necessity of conservation.
Salvatore Antonio Biancardo, Francesca Russo, Rosa Veropalumbo, Viktoras Vorobjovas, Gianluca Dell’Acqua   +4 more
doaj   +1 more source

Density Estimation Trees as fast non-parametric modelling tools

, 2016
Density Estimation Trees (DETs) are decision trees trained on a multivariate dataset to estimate its probability density function. While not competitive with kernel techniques in terms of accuracy, they are incredibly fast, embarrassingly parallel and ...
Anderlini, Lucio
core   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Parametric Modelling Techniques for Rhine Castle Models in Blender

Heritage
Recent advances in 3D modelling have greatly improved the digital reconstruction of historic buildings. Traditional 3D modelling methods, while accurate, are very time-consuming and require a detailed focus on complex architectural features.
Etienne Sommer, Mathieu Koehl, Pierre Grussenmeyer   +2 more
doaj   +1 more source

Inflation Rate Modelling in Indonesia [PDF]

, 2016
The purposes of this research were to analyse: (i) Modelling the inflation rate in Indonesia with parametric regression. (ii) Modelling the inflation rate in Indonesia using non-parametric regression spline multivariable (iii) Determining the best model ...
Caraka, R. E. (Rezzy), Sugiyarto, W. (Wawan)   +1 more
core   +2 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source