Results 51 to 60 of about 668,152 (312)

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Automated technique for high-pressure water-based window cleaning and accompanying parametric study.

open access: yesPLoS ONE, 2020
The maintenance of buildings has become an important issue with the construction of many high-rise buildings in recent years. However, the cleaning of the outer walls of buildings is performed in highly hazardous environments over long periods, and many ...
Youngjoo Lee   +4 more
doaj   +1 more source

Reduction of Feynman integrals in the parametric representation II: reduction of tensor integrals

open access: yesEuropean Physical Journal C: Particles and Fields, 2021
In a recent paper by the author (Chen in JHEP 02:115, 2020), the reduction of Feynman integrals in the parametric representation was considered. Tensor integrals were directly parametrized by using a generator method.
Wen Chen
doaj   +1 more source

Investigation on the Design of Double-Stage Scissor Lifts Based on Parametric Dimension Technique

open access: yesMachines, 2023
Scissor lifts are widely used in industry. The selection of a configuration of lift table system plays an important role since this depends on the working requirements of the systems and also the type of lift object.
Anh-Tuan Dang, Thi Thanh Nga Nguyen
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Variable damping and coherence in a high-density magnon gas

open access: yes, 2011
We report on the fast relaxation behavior of a high-density magnon gas created by a parametric amplification process. The magnon gas is probed using the technique of spin-wave packet recovery by parallel parametric pumping.
A. A. Serga   +5 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Robust Output Synchronization of Arrays of Chaotic Sprott Circuits

open access: yesAdvances in Mathematical Physics, 2017
This article presents a technique for synchronizing arrays of a class of chaotic systems known as Sprott circuits. This technique can be applied to different topologies and is robust to parametric uncertainties caused by tolerances in the electronic ...
Ernesto V. Gonzalez Solis   +1 more
doaj   +1 more source

Semi-parametric regression: Efficiency gains from modeling the nonparametric part

open access: yes, 2011
It is widely admitted that structured nonparametric modeling that circumvents the curse of dimensionality is important in nonparametric estimation. In this paper we show that the same holds for semi-parametric estimation.
Mammen, Enno   +2 more
core   +1 more source

Squeezing in the audio gravitational wave detection band [PDF]

open access: yes, 2004
We demonstrate the generation of broad-band continuous-wave optical squeezing down to 200Hz using a below threshold optical parametric oscillator (OPO). The squeezed state phase was controlled using a noise locking technique.
A. Rüdiger   +11 more
core   +3 more sources

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