Results 71 to 80 of about 668,152 (312)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Parametric optimisation of PDMS/PMMA nanofibers prepared using emulsion electrospinning technique

Results in Materials
With the massive potential for nanofiber applications within the expanding field of functional materials and green energy materials, electrospinning has become an increasingly interesting method of fabrication, generating many different methods to ...
Ryan Walden, Irthasa Aazem, Steven Hinder, Barry Brennan, Amit Goswami, Gerard McGranaghan, Suresh C. Pillai   +6 more
doaj   +1 more source

Dynamical two-mode squeezing of thermal fluctuations in a cavity opto-mechanical system

, 2015
We report the experimental observation of two-mode squeezing in the oscillation quadratures of a thermal micro-oscillator. This effect is obtained by parametric modulation of the optical spring in a cavity opto-mechanical system.
Bonaldi, M., Borrielli, A., Marconi, L., Marin, F., Marino, F., Pandraud, G., Pontin, A., Prodi, G. A., Sarro, P. M., Serra, E.   +9 more
core   +1 more source

Tunable control of the bandwidth and frequency correlations of entangled photons [PDF]

, 2006
We demonstrate experimentally a new technique to control the bandwidth and the type of frequency correlations (correlation, anticorrelation, and even uncorrelation) of entangled photons generated by spontaneous parametric downconversion.
Aichele, Di Trapani, Giovannetti, Grice, Hong, J. P. Torres, Keller, Kuzucu, Liu, M. Hendrych, M. Micuda, Martínez, Martínez, Rubin, Torres, Torres, Torres, U'Ren, U'Ren, Walton   +19 more
core   +2 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Time-domain green's function-based parametric sensitivity analysis of multiconductor transmission lines [PDF]

, 2012
We present a new parametric macromodeling technique for lossy and dispersive multiconductor transmission lines. This technique can handle multiple design parameters, such as substrate or geometrical layout features, and provide time-domain sensitivity ...
Antonini, Giulio, Dhaene, Tom, Ferranti, Francesco, Knockaert, Luc, Spina, Domenico, Vande Ginste, Dries   +5 more
core   +2 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Parametric Projection Operator Technique for Second Order Non-linear Response

, 2012
We demonstrate the application of the recently introduced parametric projector operator technique to a calculation of the second order non-linear optical response of a multilevel molecular system.
Abramavicius, Abramavičius, Argyres, Cho, Doll, Engel, Fain, Gelin, Ishizaki, Ishizaki, Jan Olšina, Jonas, Kjellberg, Mančal, Mančal, Mančal, May, Mukamel, Mukamel, Nemeth, Nemeth, Novoderezhkin, Novoderezhkin, Olšina, Palmieri, Pisliakov, Read, Rhee, Richter, Tanimura, Tomáš Mančal, van Amerongen, van Grondelle, Zhang, Zigmantas   +34 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Generation of squeezed light with monolithic optical parametric oscillator: Simultaneous achievement of phase matching and cavity resonance by temperature control

, 2010
We generate squeezed state of light at 860 nm with a monolithic optical parametric oscillator. The optical parametric oscillator consists of a periodically poled KTiOPO_4 crystal, both ends of which are spherically polished and mirror-coated.
Akira Furusawa, Aoki, Caves, Goda, Goda, Hidehiro Yonezawa, Koyo Nagashima, Lam, Masada, Mehmet, Shelby, Slusher, Suzuki, Takeno, Vahlbruch, Vahlbruch, Wu   +16 more
core   +1 more source