Results 61 to 70 of about 668,152 (312)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Parametric Optimization of Squeeze Cast AC2A-Ni Coated SiCp Composite Using Taguchi Technique

Advances in Materials Science and Engineering, 2014
This paper mainly focusses on parametric optimization of squeeze cast AC2A Ni coated SiCp composite through Taguchi technique. Composite samples have been cast through squeeze casting for each experimental trial based on L16 orthogonal array.
A. R. Ravikumar, K. S. Amirthagadeswaran, P. Senthil   +2 more
doaj   +1 more source

A Sum-of-Squares Approach to the Analysis of Zeno Stability in Polynomial Hybrid Systems

, 2013
Hybrid dynamical systems can exhibit many unique phenomena, such as Zeno behavior. Zeno behavior is the occurrence of infinite discrete transitions in finite time.
Murti, Chaitanya, Peet, Matthew
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

NOTE: non-parametric oversampling technique for explainable credit scoring

Scientific Reports
Credit scoring models are critical for financial institutions to assess borrower risk and maintain profitability. Although machine learning models have improved credit scoring accuracy, imbalanced class distributions remain a major challenge.
Seongil Han, Haemin Jung, Paul D. Yoo, Alessandro Provetti, Andrea Cali   +4 more
doaj   +1 more source

Guaranteed passive parameterized admittance-based macromodeling [PDF]

, 2010
We propose a novel parametric macromodeling technique for admittance and impedance input-output representations parameterized by design variables such as geometrical layout or substrate features. It is able to build accurate multivariate macromodels that
Dhaene, Tom, Ferranti, Francesco, Knockaert, Luc   +2 more
core   +2 more sources

Parametric High Resolution Techniques for Radio Astronomical Imaging [PDF]

IEEE Journal of Selected Topics in Signal Processing, 2008
The increased sensitivity of future radio telescopes will result in requirements for higher dynamic range within the image as well as better resolution and immunity to interference. In this paper we propose a new matrix formulation of the imaging equation in the cases of non co-planar arrays and polarimetric measurements. Then we improve our parametric
Ben-David, Chen, Leshem, Amir
openaire   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

An Adaptive Semi-Parametric and Context-Based Approach to Unsupervised Change Detection in Multitemporal Remote-Sensing Images [PDF]

, 2002
In this paper, a novel automatic approach to the unsupervised identification of changes in multitemporal remote-sensing images is proposed. This approach, unlike classical ones, is based on the formulation of the unsupervised change-detection problem in ...
Bruzzone, Lorenzo, Fernandez Prieto, Diego   +1 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source