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Neurological paraneoplastic syndromes: an update
Current Opinion in Oncology, 2018Purpose of review To describe recent advances in the diagnosis and treatment of paraneoplastic neurological syndromes (PNS). Recent findings PNS are rare complications of cancer caused by an immune cross-reaction between antigens expressed by tumor cells and neurons.
Berzero G., Psimaras D.
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The immunopathogenesis of paraneoplastic neurological syndromes
Clinical Science, 2002Paraneoplastic neurological syndromes are rare non-metastatic complications of cancer that have an immune-mediated aetiology. The central and peripheral nervous systems are considered to be immune-privileged sites, since the presence of the ‘blood-brain/nerve barrier’ means that antigens sequestered within the nervous system do not normally induce an ...
Ian, Sutton, John B, Winer
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Update on paraneoplastic neurological syndromes
Current Opinion in Oncology, 2009To describe specificities and new advances in treatment of paraneoplastic neurological syndromes (PNS).PNS are defined as neurological syndromes of unknown cause that often antedate the diagnosis of an underlying cancer that is usually not clinically evident.
Adrien, Didelot, Jérôme, Honnorat
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Diagnostics of paraneoplastic neurological syndromes
Neurological Sciences, 2017This document presents the guidelines for onconeural antibody testing that have been developed following a consensus process built on questionnaire-based surveys, internet contacts, and discussions at workshops of the sponsoring Italian Association of Neuroimmunology (AINI) congresses.
Zoccarato, Marco +20 more
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Paraneoplastic neurologic syndromes
Current Neurology and Neuroscience Reports, 2006Paraneoplastic neurologic disorders (PND) are remote medical complications of cancer that cannot be attributed to direct effects of the neoplasm or its metastases. PND are uncommon, disabling syndromes that have been recognized for more than 50 years.
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Autonomic paraneoplastic neurological syndromes
Autoimmunity Reviews, 2007Autonomic paraneoplastic neurological syndromes (PNS) typically present as chronic gastrointestinal pseudo-obstruction or orthostatic hypotension and usually occur in association with other PNS rather than in isolation. Although rare, they are often debilitating, sometimes fatal, and probably seriously underdiagnosed.
LORUSSO L +5 more
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Paraneoplastic neurological syndromes
Current Opinion in Neurology, 2002This review discusses recent advances and current controversies in the aetiology, investigation and management of paraneoplastic neurological syndromes.Antibody studies continue to define potential target autoantigens in paraneoplastic neurological syndromes and although pathogenic activity has been demonstrated for anti-glutamate receptor antibodies ...
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Advances in paraneoplastic neurological syndromes
Current Opinion in Oncology, 2004To describe specificities and new advances in paraneoplastic neurologic syndromes (PNSs).Paraneoplastic neurologic syndromes are defined as neurologic syndromes of unknown cause that often antedate the diagnosis of an underlying, usually not clinically evident, cancer.
Jérôme, Honnorat +1 more
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Diagnosis and Treatment of Paraneoplastic Neurological Syndromes
Current Clinical Pharmacology, 2008Paraneoplastic neurological syndromes (PNS) are remote effects of cancer that may involve any part of the nervous system. Rarity hinders their diagnosis and management and at least 60% of cases do not present a tumor at neurological symptoms onset. An important diagnostic element is detection, in patients' serum or cerebrospinal fluid, of onconeuronal ...
Vitaliani R, Zoccarato M, Giometto B
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Autoantibodies in Paraneoplastic Neurological Syndrome
The American Journal of the Medical Sciences, 2000Paraneoplastic neurological syndrome is a rare disorder caused by the secondary effects of cancer and is thought to be immune-mediated. A high titer of autoantibodies in the patient's serum and cerebrospinal fluid, directed against both neurons and tumor, have been detected in some forms of this syndrome.
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