Results 11 to 20 of about 6,479 (214)

Morbidity and Mortality Among People Living With HTLV-1: A 30-Year Retrospective Analysis in a Brazilian Cohort. [PDF]

J Med Virol
ABSTRACT HTLV‐1 infection is a chronic condition associated with the development of malignancies, inflammatory, and neurological disorders. In this study, the causes of hospitalization and mortality were assessed in a cohort of 508 individuals living with HTLV‐1 followed over a 30‐year period. Overall mortality was 8.5% in this population and increased
Neves ES, Espíndola OM, Oliveira RVC, Leite ACCB, Lima MASD, Silva MTT, Osellame R, Guimarães PAP, Batista RV, Oliveira ALA, Araújo AQC.   +10 more
europepmc   +2 more sources

Clinical Characteristics of Parkinsonism in HTLV-1-Associated Myelopathy. [PDF]

Ann Clin Transl Neurol
ABSTRACT Objective Human T‐lymphotropic virus type 1 (HTLV‐1)‐associated myelopathy/tropical spastic paraparesis (HAM/TSP) is the classic neurological manifestation of HTLV‐1 infection; however, this virus has also been associated with other neurological disorders. Concurrent parkinsonism is relatively rare and presents diagnostic challenges.
Dozono M, Nozuma S, Hirakata S, Yoshida T, Kodama D, Tanaka M, Matsuura E, Kubota R, Takashima H.   +8 more
europepmc   +2 more sources

Cerebrospinal Fluid From Patients With HTLV-1-associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) With Rapid Evolution Affects Mitochondrial DNA Transcription and Network Organization in Human Glioblastoma Cells. [PDF]

J Med Virol
ABSTRACT Human T‐lymphotropic virus 1 (HTLV‐1)‐associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a progressive neurodegenerative disease affecting motor and sensory functions. While alterations in cerebrospinal fluid (CSF) have been used to identify disease biomarkers, the effects of such modified CSF on CNS cells remain unexplored.
Gomes YCP, Bongers A, Jeannin P, Vicente ACP, Gessain A, Afonso PV, Espindola OM.   +6 more
europepmc   +2 more sources

Gut Microbiome Dysbiosis is Associated With Human T-Lymphotropic Virus Type 1 (HTLV-1) Infection and Disease Progression to HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis: A Cross-Sectional Study. [PDF]

Smart Med
We provide the first comprehensive analysis of changes in the gut bacteriome at different clinical stages of HTLV‐1 infection. HTLV‐1 infection is associated with a dysbiosis that includes reduced bacterial diversity and an inverted Firmicutes/Bacteroidetes ratio.
Fernandes LA, de Souza AO, Nukui Y, Marcusso RM, de Oliveira ACP, Casseb J, Clissa PB, Villas-Boas SG, Sanabani SS.   +8 more
europepmc   +2 more sources

Assessment of Awareness and Knowledge Regarding Human T-Lymphotropic Virus Type 1 (HTLV-1) Among Healthcare Workers at Imam Khomeini Hospital Complex, Tehran, in 2023-2024, A Cross-Sectional Descriptive-Analytical Study. [PDF]

Health Sci Rep
ABSTRACT Background and Aim Human T‐Lymphotropic Virus Type 1 (HTLV‐1), is responsible for serious diseases such as Adult T‐cell leukemia/lymphoma (ATLL) and HTLV‐1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). This research aimed to explore the level of awareness and knowledge of HTLV‐1 among healthcare professionals working at Imam ...
Letafati A, Goudarzi Y, Sheikhi M, Afzali M, Norouzi M, Rouzbahani KA, Ghasemi M, Sadeghi A, Mozhgani SH.   +8 more
europepmc   +2 more sources

Intravesical injection of onabotulinumtoxinA in neurogenic overactive bladder patients with human T‐cell leukemia virus type 1‐associated myelopathy: A single‐institution case series

IJU Case Reports, 2021
Introduction Neurogenic overactive bladder is a main feature of human T‐cell leukemia virus type 1‐associated myelopathy/tropical spastic paraparesis. We successfully performed intravesical onabotulinumtoxinA therapy for refractory neurogenic overactive ...
Tomohiro Matsuo, Tatsufumi Nakamura, Katsuya Sato, Yasuyoshi Miyata, Hideki Sakai   +4 more
doaj   +1 more source

Human T-Lymphotropic Virus Type 1-Associated Myelopathy With Autoimmune Cholangiopathy: An Unusual Immune Conundrum in a Young Patient. [PDF]

Case Rep Infect Dis
Human​ T‐lymphotropic virus type 1 (HTLV‐1), the first oncogenic retrovirus discovered in humans, is primarily associated with two disease entities: adult T cell leukemia‐lymphoma and HTLV‐1‐associated myelopathy‐tropical spastic paresis. HTLV‐1 has also been implicated in the pathogenesis of various autoimmune rheumatic diseases, and its association ...
Saad A, Jadoon Y, Sabir R.
europepmc   +2 more sources

Epidemiology and Clinical Outcomes of HTLV-1: A Comprehensive Narrative Review of Endemic and Nonendemic Regions. [PDF]

Can J Infect Dis Med Microbiol
Human T‐lymphotropic virus Type 1 (HTLV‐1) is a globally distributed, oncogenic retrovirus endemic in specific regions, including southwestern Japan, sub‐Saharan Africa, the Caribbean, parts of South America (notably Brazil), Iran, and Indigenous communities in Australia. Although most infections are asymptomatic, a minority of carriers develop severe,
Noori B, Shahbahrami R, Douzandegan Y, Mozhgani SH, Norouzi M, Jazayeri SM.   +5 more
europepmc   +2 more sources

Aquaporin-4 Antibodies Are Not Related to HTLV-1\ud Associated Myelopathy [PDF]

, 2012
Introduction: The seroprevalence of human T-cell leukemia virus type 1 (HTLV-1) is very high among Brazilians (,1:200).\ud HTLV-1 associated myelopathy or tropical spastic paraparesis (HAM/TSP) is the most common neurological complication of\ud HTLV-1 ...
Brandão, Carlos Otávio, Casseb, Jorge Simão do Rosário, Damasceno, Alfredo, Damasceno, Benito P., Farias, Alessandro S., Jarius, Sven, Longhini, Ana Leda F., Moraes, Adriel S., Oliveira, Augusto C. Penalva de, Santos, Leonilda M. B., von Gleh, Felipe, Wandinger, Klaus-Peter, Wildemann, Brigitte   +12 more
core   +8 more sources

Effect of pulsed methylprednisolone on pain, in patients with HTLV-1-associated myelopathy [PDF]

, 2016
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is an immune mediated myelopathy caused by the human T-lymphotropic virus type 1 (HTLV-1). The efficacy of treatments used for patients with HAM/TSP is uncertain.
Adonis, A, Buell, KG, Demontis, MA, Dhasmana, D, Haddow, J, Martin, F, Puri, A, Short, CL, Taylor, GP   +8 more
core   +1 more source