Results 11 to 20 of about 3,685 (164)

Morbidity and Mortality Among People Living With HTLV-1: A 30-Year Retrospective Analysis in a Brazilian Cohort. [PDF]

J Med Virol
ABSTRACT HTLV‐1 infection is a chronic condition associated with the development of malignancies, inflammatory, and neurological disorders. In this study, the causes of hospitalization and mortality were assessed in a cohort of 508 individuals living with HTLV‐1 followed over a 30‐year period. Overall mortality was 8.5% in this population and increased
Neves ES, Espíndola OM, Oliveira RVC, Leite ACCB, Lima MASD, Silva MTT, Osellame R, Guimarães PAP, Batista RV, Oliveira ALA, Araújo AQC.   +10 more
europepmc   +2 more sources

Clinical Characteristics of Parkinsonism in HTLV-1-Associated Myelopathy. [PDF]

Ann Clin Transl Neurol
ABSTRACT Objective Human T‐lymphotropic virus type 1 (HTLV‐1)‐associated myelopathy/tropical spastic paraparesis (HAM/TSP) is the classic neurological manifestation of HTLV‐1 infection; however, this virus has also been associated with other neurological disorders. Concurrent parkinsonism is relatively rare and presents diagnostic challenges.
Dozono M, Nozuma S, Hirakata S, Yoshida T, Kodama D, Tanaka M, Matsuura E, Kubota R, Takashima H.   +8 more
europepmc   +2 more sources

Cerebrospinal Fluid From Patients With HTLV-1-associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) With Rapid Evolution Affects Mitochondrial DNA Transcription and Network Organization in Human Glioblastoma Cells. [PDF]

J Med Virol
ABSTRACT Human T‐lymphotropic virus 1 (HTLV‐1)‐associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a progressive neurodegenerative disease affecting motor and sensory functions. While alterations in cerebrospinal fluid (CSF) have been used to identify disease biomarkers, the effects of such modified CSF on CNS cells remain unexplored.
Gomes YCP, Bongers A, Jeannin P, Vicente ACP, Gessain A, Afonso PV, Espindola OM.   +6 more
europepmc   +2 more sources

Gut Microbiome Dysbiosis is Associated With Human T-Lymphotropic Virus Type 1 (HTLV-1) Infection and Disease Progression to HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis: A Cross-Sectional Study. [PDF]

Smart Med
We provide the first comprehensive analysis of changes in the gut bacteriome at different clinical stages of HTLV‐1 infection. HTLV‐1 infection is associated with a dysbiosis that includes reduced bacterial diversity and an inverted Firmicutes/Bacteroidetes ratio.
Fernandes LA, de Souza AO, Nukui Y, Marcusso RM, de Oliveira ACP, Casseb J, Clissa PB, Villas-Boas SG, Sanabani SS.   +8 more
europepmc   +2 more sources

Assessment of Awareness and Knowledge Regarding Human T-Lymphotropic Virus Type 1 (HTLV-1) Among Healthcare Workers at Imam Khomeini Hospital Complex, Tehran, in 2023-2024, A Cross-Sectional Descriptive-Analytical Study. [PDF]

Health Sci Rep
ABSTRACT Background and Aim Human T‐Lymphotropic Virus Type 1 (HTLV‐1), is responsible for serious diseases such as Adult T‐cell leukemia/lymphoma (ATLL) and HTLV‐1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). This research aimed to explore the level of awareness and knowledge of HTLV‐1 among healthcare professionals working at Imam ...
Letafati A, Goudarzi Y, Sheikhi M, Afzali M, Norouzi M, Rouzbahani KA, Ghasemi M, Sadeghi A, Mozhgani SH.   +8 more
europepmc   +2 more sources

Syringohydromyelia or HTLV-I-associated myelopathy/tropical spastic paraparesis: a diagnostic challenge (case report) [PDF]

Arquivos de Neuro-Psiquiatria, 1999
Human T-cell lymphotropic virus type I (HTLV-I) associated myelopathy / tropical spastic paraparesis (HAM/TSP) is the most common chronic myelopathy in Brazil.
ABELARDO DE QUEIROZ-CAMPOS ARAÚJO, ANA CLAÚDIA CELESTINO BEZERRA LEITE, ANDRÉ LUIZ DOS ANJOS DE OLIVEIRA, CRISTIANE RIBEIRO DE ALMEIDA AFONSO, JULIANA PIES   +4 more
doaj   +1 more source

Caracterização molecular do HTLV-1 em pacientes com paraparesia espástica tropical/mielopatia associada ao HTLV-1 em Belém, Pará Molecular characterization of HTLV-1 among patients with tropical spastic paraparesis/HTLV-1 associated myelopathy in Belém, Pará

Revista da Sociedade Brasileira de Medicina Tropical, 2006
O presente estudo avaliou a ocorrência da infecção pelo HTLV-1 e seus subtipos em amostras de sangue de pacientes com diagnóstico clínico de paraparesia espástica tropical/mielopatia associada ao Htlv-1.
Lucinda A. Souza, Ivina G.L. Lopes, Eduardo Leitão Maia, Vânia N. Azevedo, Luiz Fernando A. Machado, Marluísa O.G. Ishak, Ricardo Ishak, Antonio Carlos R. Vallinoto   +7 more
doaj   +1 more source

HTLV-1 and HIV-1 co-infection: A case report and review of the literature

IDCases, 2016
HTLV type 1 and 2 are both involved in actively spreading epidemics, affecting over 15 million people worldwide. HTLV-1 has been described as the more clinically significant one, being associated with diseases such as adult T-cell leukemia and tropical ...
Carmen Isache, Michael Sands, Nilmarie Guzman, Danisha Figueroa   +3 more
doaj   +1 more source

HTLV-I negative tropical spastic paraparesis: a scientific challenge Paraparesia espástica tropical HTLV-I negativa: um desafio científico

Arquivos de Neuro-Psiquiatria, 2001
We reviewed the historical, clinical and etiological aspects of the progressive chronic spastic myelopathies of unknown etiology, disserting on the clinical similarities between HTLV-I seropositive and seronegative tropical spastic paraparesis (TSP), as ...
Carlos Mauricio De Castro-Costa, Herwig Carton, Terezinha J. T. Santos   +2 more
doaj   +1 more source

INTERFERON BETA-1A TREATMENT IN HTLV-1-ASSOCIATED MYELOPATHY/TROPICAL SPASTIC PARAPARESIS: A CASE REPORT

Revista do Instituto de Medicina Tropical de São Paulo, 2014
Here a young patient (< 21 years of age) with a history of infective dermatitis is described. The patient was diagnosed with myelopathy associated with HTLV-1/tropical spastic paraparesis and treated with interferon beta-1a.
Graça Maria de Castro Viana, Marcos Antonio Custódio Neto da Silva, Victor Lima Souza, Natália Barbosa da Silva Lopes, Diego Luz Felipe da Silva, Maria do Desterro Soares Brandão Nascimento   +5 more
doaj   +1 more source