Results 41 to 50 of about 50,475 (278)

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Paraplegia after coronary artery bypass surgery: An uncommon complication in a patient with history of thoracic endovascular aortic repair

Journal of Vascular Surgery Cases and Innovative Techniques, 2018
Neurologic lesions are unusual complications after coronary artery bypass surgery. Among them, paraplegia is one of the rarest, with only a few cases reported in the literature.
Aurélien Vallée, MD, Stephan Haulon, MD, PhD, Alexandre Azmoun, MD, Julien Guihaire, MD, PhD   +3 more
doaj   +1 more source

Flaccid paraplegia of organophosphate-induced delayed polyneuropathy leading to early spastic paraplegia. Case report

, 2015
Organophosphate insecticides have been widely used for pest control. They have been readily used as a suicidal agent in developing countries. This paper reports the case of a middle aged male patient with acute organophosphate compound poisoning who in
Kiran Buddaraju, Anish Mehta, Abhinandan K. Shankar, Rohan Mahale, Rangasetty Srinivasa   +4 more
core   +1 more source

GAD65 Antibody ELISA With Extended Reportable Range: Validation and Guidance for Neurological Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon, Dana Olofson, Diana Anissian, Divyanshu Dubey, Eoin P. Flanagan, Max C. Herman, Sarosh R. Irani, Daniel H. Lachance, Maria A. Willrich, Sean Pittock, John R. Mills, Anastasia Zekeridou   +11 more
wiley   +1 more source

Case Report: Anesthetic Management of Cesarean Section in a Patient With Paraplegia

Frontiers in Medicine, 2022
BackgroundWith the advancement of medical science and rehabilitative care, more women with spinal cord injury (SCI) can conceive. However, autonomic hyperreflexia due to SCI complicates anesthesia management during cesarean sections.Case PresentationThis
Yongchun Su, Xiaofeng Lei, Jin Yu
doaj   +1 more source

Movement Disorders in Aicardi–Goutières Syndrome and Response to Immunomodulation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This study characterizes movement disorders and treatment responses in seven children with Aicardi–Goutières syndrome (AGS). We retrospectively evaluated motor phenotypes, neuroimaging, and interferon signatures in patients treated with baricitinib or anifrolumab. Spasticity affected all patients, while dystonia was present in 4/7.
Enrique Gonzalez Saez‐Diez, Monica Ferrer Socorro, Kathryn Yang, Nicole Battaglia, Zainab Zaman, Mariko Bennett, Adeline Vanderver, Pui Y. Lee, Lauren A. Henderson, Milena M. Andzelm, Darius Ebrahimi‐Fakhari   +10 more
wiley   +1 more source

Simultaneous treatment of sacral and ischial pressure ulcers with a single flap: case presentation [PDF]

Revista Brasileira de Cirurgia Plástica, 2018
Pressure ulcers are alterations of the integrity of the skin and underlying tissues, caused by pressure, more commonly on bony prominences, especially in areas devoid of sensitivity, which lead to necrosis and ulceration.
Antonio Chiquetti Junior, Renato Da Silva Freitas   +1 more
doaj   +1 more source

Safety and Feasibility of a Novel Exoskeleton for Locomotor Rehabilitation of Subjects With Spinal Cord Injury: A Prospective, Multi-Center, and Cross-Over Clinical Trial

Frontiers in Neurorobotics, 2022
ObjectiveTo evaluate the safety, walking efficiency, physiological cost, don and doff time cost, and user satisfaction of Ai-robot.DesignProspective, multi-center, and cross-over trial.SubjectsParaplegic subjects (n = 40) with T6–L2 level spinal cord ...
Sijing Chen, Sijing Chen, Zhanbin Wang, Yongqiang Li, Yongqiang Li, Jiashuai Tang, Xue Wang, Xue Wang, Liping Huang, Zhuangwei Fang, Tao Xu, Jiang Xu, Feng Guo, Yizhao Wang, Jianjun Long, Jianjun Long, Xiaodong Wang, Xiaodong Wang, Fang Liu, Fang Liu, Jianfeng Luo, Jianfeng Luo, Jianfeng Luo, Yulong Wang, Yulong Wang, Xiaolin Huang, Zishan Jia, Mei Shuai, Jianan Li, Jianan Li   +29 more
doaj   +1 more source

Can Multiple Sclerosis be Managed Over a Lifetime? A Rare 72-Year Journey of Pediatric-Onset to Secondary Progressive Multiple Sclerosis. [PDF]

Clin Case Rep
ABSTRACT Multiple sclerosis (MS) is a chronic demyelinating disorder of the central nervous system characterized by cumulative neurological disability over time. Median survival from symptom onset in large cohort studies is approximately four decades, although substantially prolonged disease courses are uncommon.
Etemadifar M, Dehghani A, Rahimi M, Ghandehari A, Salari M.   +4 more
europepmc   +2 more sources

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source