Results 71 to 80 of about 110,945 (357)

Regulating PPARG Reduces Lipid Accumulation in Microglia and Promotes Functional Recovery After Spinal Cord Injury

Advanced Science, EarlyView.
Macrophages infiltrate the spinal cord post‐injury, decreasing over time. Microglia phagocytose myelin debris, increasing lipid accumulation. Macrophage deletion improves outcomes, while microglial deletion worsens them. The LD+ microglia subtype shows abnormal Pparg signaling.
Mingran Luo, Jiayun Liu, Yunxin Su, Tao Jiang, Xincan Wu, Peng Gao, Tao Qin, Mengyuan Wu, Qingqing Li, Shujun Zhang, Baorong He, Yongxiang Wang, Xiaodong Guo, Wei Zhou, Shujie Zhao, Jin Fan, Jian Chen, Guoyong Yin   +17 more
wiley   +1 more source

Paraplegia aguda. Uma complicação rara da dissecção aórtica Acute paraplegia. A rare complication of aortic dissection

Arquivos Brasileiros de Cardiologia, 1998
Mulher normotensa de 67 anos desenvolveu síncope, seguida de choque, e, mesmo após estabilização hemodinâmica, permaneceu anúrica. Observaram-se paraplegia e paresia do membro superior direito, além de isquemia das extremidades distais dos membros ...
Renato Côrtes de Lacerda, Patrícia Bernard Andrea, Evaristo Machado Neto, Carlos Baptista de Figueiredo, Alfredo Brasil Teixeira, Paulo Cézar Monteiro de Carvalho   +5 more
doaj   +1 more source

Role of peripheral quantitative computed tomography in identifying disuse osteoporosis in paraplegia [PDF]

, 2009
Objective: Disuse osteoporosis is a major long-term health consequence of spinal cord injury (SCI) that still needs to be addressed. Its management in SCI should begin with accurate diagnosis, followed by targeted treatments in the most vulnerable ...
A Frotzler, A Frotzler, AA Freehafer, Alan N. McLean, B Chen, David B. Allan, ED Bruin de, HH Bolotin, HM Frost, J Rittweger, JL Ferretti, L Giangregorio, L Maimoun, M Bélanger, P Eser, P Eser, P Eser, P Frey-Rindova, P Vestergaard, S Dudley-Javoroski, S-D Jiang, Sylvie Coupaud, T Mohr   +22 more
core   +1 more source

Molecular Design of a Naturally Derived Hemostatic Sealant with Prolonged Antimicrobial Activity for Repairing Elastic Organ Injuries

Advanced Science, EarlyView.
An injectable, photocrosslinkable hydrogel sealant—comprising GelMAG, DMA, and pDDA—demonstrated strong underwater adhesion, elasticity, biocompatibility, and broad‐spectrum antibacterial activity. This material rapidly sealed dynamic internal organ injuries and significantly reduced blood loss in vivo. Its superior performance over commercial products
Saumya Jain, Avijit Baidya, Joshua A. Boys, George Z. Cheng, Taichiro Imahori, Naoki Kaneko, Nasim Annabi   +6 more
wiley   +1 more source

Spinal Tuberculosis with Paraplegia in Pregnancy: a Case Report with Management of Spinal TB in Pregnancy

Journal of Nepal Medical Association, 2015
Spinal tuberculosis leading to paraplegia is uncommon in pregnancy and is a diagnostic and therapeutic challenge. We report a case of tubercular paraplegia presenting at 35 weeks of gestation.
Sushruti Kaushal, Santosh Kumar Dora, Sunil Thakur   +2 more
doaj   +1 more source

Paraplegic Patient for Lower Limb Surgery: Monitored Anesthesia Care (MAC) as an Alternative Approach

MAMC Journal of Medical Sciences, 2022
Patients with spinal cord injury 4–8 weeks back presenting for non-spinal elective surgery, present a unique challenge to the anesthesiologist. The perioperative concerns include potential for perioperative autonomic hypereflexia, muscle spasms ...
Bharti Wadhwa, Kirti N Saxena, Mousumi Saha   +2 more
doaj   +1 more source

How to allocate scarce health resources without discriminating against people with disabilities [PDF]

, 2016
One widely used method for allocating health care resources involves the use of cost-effectiveness analysis (CEA) to rank treatments in terms of quality-adjusted life-years (QALYs) gained.
John, Tyler M., Millum, Joseph, Wasserman, David   +2 more
core   +1 more source

Dnmt1 Alleviates S1PR1‐Mediated Pyroptosis after Spinal Cord Injury through Regulating Pon3 Expression

Advanced Science, EarlyView.
This study systematically explores the action mechanism of Pon3 and its regulatory targets in spinal cord injury (SCI). It demonstrates that Dnmt1 regulates Pon3 expression by modulating methylation levels, thereby inhibiting S1PR1‐mediated pyroptosis and improving SCI prognosis.
Birong Peng, Haolong Lin, Mi Zhang, Wenhao Kuang, Jiaqi Zhang, Shuai Wang, Yuanfang Sun, Wenning Xu, Lixin Zhu   +8 more
wiley   +1 more source

Targeted high throughput sequencing in hereditary ataxia and spastic paraplegia

PLoS ONE, 2017
Hereditary ataxia and spastic paraplegia are heterogeneous monogenic neurodegenerative disorders. To date, a large number of individuals with such disorders remain undiagnosed.
Z. Iqbal, S. L. Rydning, I. Wedding, J. Koht, L. Pihlstrøm, A. Rengmark, S. P. Henriksen, C. Tallaksen, M. Toft   +8 more
semanticscholar   +1 more source

Biallelic Variants in the DARS2 Gene as a Novel Cause of Axonal Charcot–Marie–Tooth Disease

Annals of Neurology, EarlyView.
Objective Charcot–Marie–Tooth (CMT) disease is a heterogeneous group of genetic neuropathies, with >90 genes identified. Several aminoacyl‐tRNA synthetases have been linked to CMT. DARS2, encoding the mitochondrial aspartyl‐tRNA synthetase, has been typically associated with leukoencephalopathy with brainstem and spinal cord involvement and lactate ...
Berta Estévez‐Arias, Siiri Sarv, Nathalie Bonello‐Palot, Laura Carrera‐García, Carlos Ortez, Jesica Expósito‐Escudero, Delia Yubero, Jordi Muchart, Emilien Delmont, Eve Õiglane‐Shlik, Teele Meren, Sanna Puusepp, Ülle Murumets, Gajja S. Salomons, Bjarne Udd, Liis Väli, Lara Cantarero, Carsten G. Bönnemann, Andrés Nascimento, Santiago Ramón‐Maiques, Katrin Õunap, Janet Hoenicka, Daniel Natera‐de Benito, Francesc Palau   +23 more
wiley   +1 more source