Results 41 to 50 of about 2,258 (153)

Advancing ORFV‐Based Therapeutics to the Clinical Stage

Reviews in Medical Virology, Volume 35, Issue 3, May 2025.
ABSTRACT The Orf virus (ORFV) is the prototype member of the parapoxvirus family and has long been recognized for its robust immunogenicity, favourable safety profile and its ability to stimulate both cellular and humoural immune responses without inducing significant anti‐vector immunity.
Matthias Helmold, Ralf Amann
wiley   +1 more source

Protective immune response against Rhodococcus equi: An innate immunity‐focused review

Equine Veterinary Journal, Volume 57, Issue 3, Page 563-586, May 2025.
Abstract Rhodococcus equi causes pyogranulomatous pneumonia in foals and immunocompromised people. Despite decades of research efforts, no vaccine is available against this common cause of disease and death in foals. The purpose of this narrative review is to summarise the current understanding of interactions between R. equi and the host innate immune
Bibiana Petri da Silveira, Noah D. Cohen, Sara D. Lawhon, Robert O. Watson, Angela I. Bordin   +4 more
wiley   +1 more source

Orf Virus Encoded Protein ORFV119 Induces Cell Apoptosis Through the Extrinsic and Intrinsic Pathways

Frontiers in Microbiology, 2018
Apoptosis, a significant form of cell death, has a leading role in the host cell defense against virus infection. Viruses have evolved a series of strategies that block apoptosis during the early stage of viral infection to enhance viral replication, and
Wei Li, Huiqin Chen, Hao Deng, Zhenzhan Kuang, Mingjian Long, Daxiang Chen, Xiaoqing Liao, Ming Li, Ming Li, Daniel L. Rock, Shuhong Luo, Shuhong Luo, Wenbo Hao, Wenbo Hao   +13 more
doaj   +1 more source

Characterisation and Sensitivity of a Canine Mast Cell Tumour Line to Oncolytic Viruses

Veterinary and Comparative Oncology, Volume 23, Issue 1, Page 42-51, March 2025.
ABSTRACT Canine mast cell tumours (MCTs) are one of the most common skin cancers of dogs. Surgical removal is the primary treatment, but recurrence and metastasis can occur even with low‐grade tumours. As a result, new treatment strategies are being sought.
Yeganeh Mehrani, Julia E. Kakish, Christina Napoleoni, Jennifer Jane Thompson, Jason P. Knapp, Jessica A. Minott, Jacob G. E. Yates, Deirdre Stuart, Brenda L. Coomber, Robert A. Foster, Byram W. Bridle, Khalil Karimi   +11 more
wiley   +1 more source

Novel Multi-Antigen Orf-Virus-Derived Vaccine Elicits Protective Anti-SARS-CoV-2 Response in Monovalent and Bivalent Formats

Vaccines
Prime-2-CoV_Beta is a novel Orf virus (ORFV)-based COVID-19 vaccine candidate expressing both the nucleocapsid and spike proteins of SARS-CoV-2 with the receptor-binding domain (RBD) of the Beta strain. This candidate was shown to be safe and immunogenic
Dominique Julien Burri, Louis Renz, Melanie Mueller, Felix Pagallies, Ute Klinkhardt, Ralf Amann, Madiha Derouazi   +6 more
doaj   +1 more source

Infectious Disease Outbreak Associated With Supplementary Feeding of Semi-domesticated Reindeer

Frontiers in Veterinary Science, 2019
Supplementary winter feeding of semi-domesticated reindeer (Rangifer tarandus tarandus) has become more common in Sweden and Norway due to reindeer pasture fragmentation and climatic conditions.
Morten Tryland, Ingebjørg H. Nymo, Ingebjørg H. Nymo, Javier Sánchez Romano, Torill Mørk, Jörn Klein, Ulrika Rockström   +6 more
doaj   +1 more source

Oncolytic Parapoxvirus induces Gasdermin E-mediated pyroptosis and activates antitumor immunity

Nature Communications, 2023
Oncolytic viruses are able to target tumours and thought to induce apoptosis while remodelling the tumour immune microenvironment. Here authors show in an oncolytic parapoxvirus ovis model that pyroptosis, a highly immunogenic Gasdermin-E-dependent cell ...
Jing Lin, Shihui Sun, Kui Zhao, Fei Gao, Renling Wang, Qi Li, Yanlong Zhou, Jing Zhang, Yue Li, Xinyue Wang, Le Du, Shuai Wang, Zi Li, Huijun Lu, Yungang Lan, Deguang Song, Wei Guo, Yujia Chen, Feng Gao, Yicheng Zhao, Rongrong Fan, Jiyu Guan, Wenqi He   +22 more
doaj   +1 more source

Parapoxvirus Infections of Red Deer, Italy

Emerging Infectious Diseases, 2011
To characterize parapoxviruses causing severe disease in wild ruminants in Stelvio Park, Italy, we sequenced and compared the DNA of several isolates. Results demonstrated that the red deer isolates are closely related to the parapox of red deer in New ...
Alessandra Scagliarini, Francesca Vaccari, Filippo Turrini, Alessandro Bianchi, Paolo Cordioli, Antonio Lavazza   +5 more
doaj   +1 more source

Next‐Generation Vaccines for Co‐Circulating PEDV and TGEV: Integrating Nucleic Acid Platforms, Mucosal Delivery, and AI–Driven Antigen Design

Transboundary and Emerging Diseases, Volume 2025, Issue 1, 2025.
Porcine epidemic diarrhea virus (PEDV) and transmissible gastroenteritis virus (TGEV) are causative agents of acute enteric diseases in pigs and have a high contagion potential. These coronaviruses (CoVs) impose substantial economic losses on global pork production, particularly affecting lactating piglets where coinfections occur. Although traditional
Xiaojun Hu, Zhenshan Wang, Shen Wang, Hongyu Sun, Na Feng, Entao Li, Xianzhu Xia, Guixue Hu, Feihu Yan, Bin Li   +9 more
wiley   +1 more source

Sheep-to-Human Transmission of Orf Virus during Eid al-Adha Religious Practices, France

Emerging Infectious Diseases, 2013
Five persons in France were infected with Orf virus after skin wounds were exposed to infected sheep tissues during Eid al-Adha, the Muslim Feast of Sacrifice. Infections were confirmed by electron microscopy, PCR, and sequence analysis.
Antoine Nougairede, Christelle Fossati, Nicolas Salez, Stephan Cohen-Bacrie, Laetitia Ninove, Fabrice Michel, Samer Aboukais, Mathias Buttner, Christine Zandotti, Xavier de Lamballerie, Remi N. Charrel   +10 more
doaj   +1 more source