Results 71 to 80 of about 4,205 (246)

Oncolytic Parapoxvirus induces Gasdermin E-mediated pyroptosis and activates antitumor immunity

Nature Communications, 2023
Oncolytic viruses are able to target tumours and thought to induce apoptosis while remodelling the tumour immune microenvironment. Here authors show in an oncolytic parapoxvirus ovis model that pyroptosis, a highly immunogenic Gasdermin-E-dependent cell ...
Jing Lin, Shihui Sun, Kui Zhao, Fei Gao, Renling Wang, Qi Li, Yanlong Zhou, Jing Zhang, Yue Li, Xinyue Wang, Le Du, Shuai Wang, Zi Li, Huijun Lu, Yungang Lan, Deguang Song, Wei Guo, Yujia Chen, Feng Gao, Yicheng Zhao, Rongrong Fan, Jiyu Guan, Wenqi He   +22 more
doaj   +1 more source

Studies On The Pathogenesis Of Contagious Ecthyma In Goats And Sheep [PDF]

, 1994
Local contagious ecthyma viruses isolated from sheep (Lb) and goats (GV 1 and GV 2) were used in a series of infection trials in kids and lambs to compare the pathogenesis, virus virulence and host susceptibility.
Ismail, Roshidah
core  

Genetic and Antigenic Heterogeneity of Different Parapoxvirus Strains

Intervirology, 1980
Six stomatitis papulosa and three Orf virus strains were compared by serology and by DNA restriction analysis. A neutralization kinetic study revealed extensive serological cross-reactivity between all strains, but did not allow their classification. Restriction analysis of viral DNAs revealed two distinct groups among the stomatitis papulosa strains ...
R, Wittek, M, Herlyn, D, Schümperli, P A, Bachmann, A, Mayr, R, Wyler   +5 more
openaire   +2 more sources

Novel Multi-Antigen Orf-Virus-Derived Vaccine Elicits Protective Anti-SARS-CoV-2 Response in Monovalent and Bivalent Formats

Vaccines
Prime-2-CoV_Beta is a novel Orf virus (ORFV)-based COVID-19 vaccine candidate expressing both the nucleocapsid and spike proteins of SARS-CoV-2 with the receptor-binding domain (RBD) of the Beta strain. This candidate was shown to be safe and immunogenic
Dominique Julien Burri, Louis Renz, Melanie Mueller, Felix Pagallies, Ute Klinkhardt, Ralf Amann, Madiha Derouazi   +6 more
doaj   +1 more source

Detection of pseudocowpox virus in water buffalo (Bubalus bubalis) with vesicular disease in the state of São Paulo, Brazil, in 2016

Veterinary Quarterly, 2017
Background: Parapoxviruses are zoonotic viruses that infect cattle, goats and sheep; there have also been reports of infections in camels, domestic cats and seals. Objective: The objective of this report was to describe a case of vesicular disease caused
Mateus Laguardia-Nascimento, Ana Paula Ferreira de Oliveira, Fernanda Rodas Pires Fernandes, Anselmo Vasconcelos Rivetti, Marcelo Fernandes Camargos, Antônio Augusto Fonseca Júnior   +5 more
doaj   +1 more source

Viral metagenomic analysis reveals potential biological hazards in non‐human primates in a zoo

Animal Research and One Health, Volume 3, Issue 2, Page 217-228, May 2025.
The investigation identifies the presence of Encephalomyocarditis virus (EMCV), Baboon endogenous virus (BAV), Human endogenous retrovirus (HERV), and Baboon endogenous virus (BaEV) in non‐human primates (NHPs) at the Zoo, indicating potential zoonotic threats.
Ruiying Liang, Xinming Tang, Lin Liang, Jiabo Ding, Ye Tian, Yixian Qin, Sufen Zhao, Lixia Zhang, Tianchun Pu, Xuefeng Liu, Jinpeng Liu, Chenglin Zhang, Zibin Li, Ting Jia   +13 more
wiley   +1 more source

Viral detection by electron microscopy: past, present and future. [PDF]

, 2008
International audienceViruses are very small and most of them can be seen only by TEM (transmission electron microscopy). TEM has therefore made a major contribution to virology, including the discovery of many viruses, the diagnosis of various viral ...
Ait-Goughoulte, Appleton, Biel, Bishop, Blanchard, Bousarghin, Brandenburg, Brandenburg, Brenner, Briggs, Brorson, Caul, Chan, Chua, Cossart, Coyne, Curry, Curry, Curry, Curry, Cyrklaff, Dane, Donahue, Drosten, Feinstone, Flewett, Forster, Frischknecht, Gaietta, Gardner, Giepmans, Goldsmith, Grabenbauer, Griffiths, Grigorov, Gruber, Grunewald, Guo, Hacein-Bey-Abina, Haguenau, Harris, Helenius, Henderson, Hourioux, Hourioux, Huovila, Jones, Jones, Jouvenet, Kapikian, Kapikian, Kartenbeck, Knoll, Ksiazek, Lanman, Literak, Logan, Logan, Lueders, Madeley, Madeley, Madeley, Madeley, Maeda, Marsh, Matz-Rensing, Mayo, McCaughey, McLauchlan, Medici, Miller, Morris, Murray, Nagler, Novoa, Oka, Patient, Pelchen-Matthews, Philippe Roingeard, Poel, Prukner-Radovcic, Reed, Rodak, Roingeard, Roux, Ruska, Ruska, Ruska, Tang, Tyrrell, Weiss, Welsch, Wileman   +92 more
core   +3 more sources

Advancing ORFV‐Based Therapeutics to the Clinical Stage

Reviews in Medical Virology, Volume 35, Issue 3, May 2025.
ABSTRACT The Orf virus (ORFV) is the prototype member of the parapoxvirus family and has long been recognized for its robust immunogenicity, favourable safety profile and its ability to stimulate both cellular and humoural immune responses without inducing significant anti‐vector immunity.
Matthias Helmold, Ralf Amann
wiley   +1 more source

Sorting Out Pandora’s Box: Discerning the Dynamic Roles of Liver Microenvironment in Oncolytic Virus Therapy for Hepatocellular Carcinoma [PDF]

, 2014
Oncolytic viral therapies have recently found their way into clinical application for hepatocellular carcinoma (HCC), a disease with limited treatment options and poor prognosis. Adding to the many intrinsic challenges of in vivo oncolytic viral therapy,
Jennifer Altomonte, Oliver Ebert
core   +3 more sources

Protective immune response against Rhodococcus equi: An innate immunity‐focused review

Equine Veterinary Journal, Volume 57, Issue 3, Page 563-586, May 2025.
Abstract Rhodococcus equi causes pyogranulomatous pneumonia in foals and immunocompromised people. Despite decades of research efforts, no vaccine is available against this common cause of disease and death in foals. The purpose of this narrative review is to summarise the current understanding of interactions between R. equi and the host innate immune
Bibiana Petri da Silveira, Noah D. Cohen, Sara D. Lawhon, Robert O. Watson, Angela I. Bordin   +4 more
wiley   +1 more source